Iron plays a vital role in several cellular functions due to its unique physiochemical
properties. Iron concentration increases in the brain with age due to multiple factors …

Several novel antioxidant-iron chelators bearing 8-hydroxyoxyquinoline moiety were
synthesized, and various properties related to their iron chelation, and neuroprotective …

Iron‐dependent oxidative stress, elevated levels of iron and of monoamine oxidase (MAO)‐
B activity, and depletion of antioxidants in the brain may be major pathogenic factors in …

Dysregulation of brain iron homeostasis is central to early neuropathological events in
Alzhei mer's disease (AD), including oxidative stress, inflam matory processes, amyloid …

Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have
been found in the brains of patients of numerous neurodegenerative disorders, including …

It is for these authors a great privilege to dedicate this review article to Moussa Youdim, who
is one of the most imperative pharmacologists and pioneer investigators in the search and …

The multifactorial nature of Alzheimer's disease (AD), and the absence of a disease
modifying drug, makes the development of new multifunctional drugs an attractive …

Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

Iron chelation has been introduced as a new therapeutic concept for the treatment of
neurodegenerative diseases with features of iron overload. At difference with iron chelators …

Neurodegenerative disorders are among the most studied issues both in medicine and
pharmacy. Despite long and extensive research, there is no effective treatment prescribed …