Genetic, biochemical, physiological, and pharmacological approaches have advanced our
understanding of cholinergic biology for over 100 years. High-affinity choline uptake (HACU) …

In cholinergic neurons, the presynaptic choline transporter (CHT) mediates high-affinity
choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has …

Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity
choline transporter CHT is essential for providing choline as substrate for synthesis of …

The cholinergic neurons have long been a model for biochemical studies of
neurotransmission. The components responsible for cholinergic neurotransmission, such as …

Current therapies to enhance CNS cholinergic function rely primarily on extracellular
acetylcholinesterase (AChE) inhibition, a pharmacotherapeutic strategy that produces dose …

Presynaptic choline uptake is vital to sustained neuronal acetylcholine (ACh) release;
however, only with the recent cloning of choline transporters (CHTs)(ie, SLC5A7), has a …

In cholinergic neurons, a specific requirement for precursor choline in the biosynthesis of
acetylcholine (ACh) is thought to be sustained by a presynaptic, hemicholinium-3 (HC-3) …

Maintenance of acetylcholine (ACh) synthesis depends on the activity of the high‐affinity
choline transporter (CHT1), which is responsible for the reuptake of choline from the …

The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine
(ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection …

Presynaptic synthesis of acetylcholine (ACh) requires a steady supply of choline, acquired
by a plasma membrane, hemicholinium-3-sensitive (HC-3) choline transporter (CHT). A …