Intermittent hypoxia (IH) occurs in association with obstructive sleep apnea and likely
contributes to the pathogenesis of hypertension. The purpose of this study was to examine …

Chronic intermittent hypoxia (CIH) is thought to be responsible for the cardiovascular
disease associated with obstructive sleep apnea (OSA). Increased sympathetic activation …

Key points Intermittent hypoxia leads to long‐lasting increases in muscle sympathetic nerve
activity and blood pressure, contributing to increased risk for hypertension in obstructive …

Repetitive hypoxic apneas, similar to those observed in sleep apnea, result in resetting of
the sympathetic baroreflex to higher blood pressures (BP). This baroreflex resetting is …

Chronic intermittent hypoxia (CIH) is a model of arterial hypoxemia that accompanies sleep
apnea and increases resting arterial pressure (AP). We examined the effects of 7days of …

In patients with obstructive sleep apnea (OSA), nocturnal exposure to intermittent hypoxia
causes elevations in arterial pressure that persist throughout the day. Animal models have …

Long-term exposure to intermittent hypoxia (IH), such as that occurring in association with
sleep apnea, may result in systemic hypertension; however, the time course changes in …

During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases
heart rate, cardiac output, peripheral resistance and systemic arterial pressure. However …

Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway
obstruction during sleep. These obstructive episodes are characterized by cyclic intermittent …

Fletcher, Eugene C. Invited Review: Physiological consequences of intermittent hypoxia:
systemic blood pressure. J Appl Physiol 90: 1600–1605, 2001.—One of the major …