[图书][B] From GWAS Hits to Treatment Targets
J Erdmann, T Zeller - 2019 - books.google.com
Genome-wide association (GWA) studies, as a prototype of large-scale OMICs studies, have
advanced our understanding of the genetic basis of many common diseases. With respect to …
advanced our understanding of the genetic basis of many common diseases. With respect to …
Advances and challenges for GWAS analysis in cardiac diseases: a focus on coronary artery disease (CAD)
SU Khan, S Saeed, AM Alsuhaibani, S Fatima… - Current Problems in …, 2023 - Elsevier
The achievement of genome-wide association studies (GWAS) has rapidly progressed our
understanding of the etiology of coronary artery disease (CAD). It unlocks new strategies to …
understanding of the etiology of coronary artery disease (CAD). It unlocks new strategies to …
Moving beyond genome-wide association studies
NL Glazer - Circulation: Cardiovascular Genetics, 2011 - Am Heart Assoc
The sequencing of the human genome1 and the subsequent completion of the human
haplotype mapping (HapMap) project2 have led to unparalleled research into the structure …
haplotype mapping (HapMap) project2 have led to unparalleled research into the structure …
Next-generation genome-wide association studies: time to focus on phenotype?
CA MacRae, RS Vasan - Circulation: Cardiovascular Genetics, 2011 - Am Heart Assoc
As investigators plan the next round of genome-wide association studies (GWAS), cohorts of
more than 100 000 individuals are being proposed as the solution to the “missing …
more than 100 000 individuals are being proposed as the solution to the “missing …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
[HTML][HTML] Translating GWAS findings to novel therapeutic targets for coronary artery disease
The success of genome-wide association studies (GWAS) has significantly advanced our
understanding of the etiology of coronary artery disease (CAD) and opens new opportunities …
understanding of the etiology of coronary artery disease (CAD) and opens new opportunities …
Understanding cardiovascular disease through the lens of genome-wide association studies
DE Arking, A Chakravarti - Trends in genetics, 2009 - cell.com
The past few years have seen significant advances in the identification of genetic factors that
contribute to complex disease. Progress in cardiovascular diseases (CVD) has been …
contribute to complex disease. Progress in cardiovascular diseases (CVD) has been …
Genetics 100 for cardiologists: basics of genome-wide association studies
JB Dubé, RA Hegele - Canadian Journal of Cardiology, 2013 - Elsevier
The spring of 2012 marked the fifth anniversary of the widespread appearance in the
biomedical literature of genome-wide association studies (GWAS) of diseases of adulthood …
biomedical literature of genome-wide association studies (GWAS) of diseases of adulthood …
GWAS applied to heart failure: bigger will be better… eventually
DM McNamara, B London - Circulation: Cardiovascular Genetics, 2010 - Am Heart Assoc
Over the last decade, the application of genetics to cardiac risk has transitioned from single
gene assessment in rare mendelian disorders to more common complex phenotypes such …
gene assessment in rare mendelian disorders to more common complex phenotypes such …
[HTML][HTML] Genetics of cardiovascular disease: fishing for causality
C Paone, F Diofano, DD Park, W Rottbauer… - Frontiers in …, 2018 - frontiersin.org
Cardiovascular disease (CVD) is still the leading cause of death in all western world
countries and genetic predisposition in combination with traditional risk factors frequently …
countries and genetic predisposition in combination with traditional risk factors frequently …