Cystic fibrosis (CF) lung disease, caused by abnormal ion transport because of deficient
CFTR (cystic fibrosis transmembrane conductance regulator) function, is characterized by a …

The primary defect in cystic fibrosis (CF) is a result of mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, which results in altered sodium and …

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance
Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized …

Cystic fibrosis (CF) lung disease involves chronic bacterial infection of retained airway
secretions (mucus). Recent data suggest that CF lung disease pathogenesis reflects the …

Individuals with cystic fibrosis (CF) suffer progressive airway inflammation, infection and
lung damage. Airway inflammation and infection are present from early in life, often before …

Background Cystic fibrosis (CF), caused by reduced CFTR function, includes severe
sinonasal disease which may predispose to lung disease. Newly developed CF pigs provide …

Antibacterial defenses in the airway are dependent on multifactorial influences that
determine the composition of both fluid and/or electrolytes at the surface of the airway and …

Cystic fibrosis (CF) is one of the most common lethal, autosomal recessive inherited
diseases among Caucasians. It is caused by a mutation in the cystic fibrosis transmembrane …

The airway surface contains a number of important defense mechanisms to protect against
infection. Antimicrobials found in the thin layer of fluid lining the airways, the airway surface …

Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is
characterized by high NaCl concentration in sweat and the production of a thick and sticky …