Bone is a hard but dynamic organ that is constantly remodeled throughout the life process.
The dynamic balance between bone resorption and bone formation is very important …

Osteoporosis is a disease that impacts the elderly. Low estrogen is related to changes in
DNA methylation and consequent alterations in gene expression, leading to a new direction …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Osteoporosis is one of the most common metabolic skeletal diseases, which affects more
than 200 million people worldwide, especially elderly and postmenopausal women. One of …

Bone is a complex connective tissue characterized by a calcified extracellular matrix. This
mineralized matrix is constantly being formed and resorbed throughout life, allowing the …

Bone has a robust regenerative potential, but its capacity to repair critical-sized bone defects
is limited. In recent years, stem cells have attracted significant interest for their potential in …

Within the eukaryotic nucleus the genomic DNA is organized into chromatin by stably
interacting with the histone proteins as well as with several other nuclear components …

Mesenchymal stem cells (MSCs) are multipotent progenitors that have the abilities of
selfrenewal and multiple direction differentiation. The osteogenic potential of MSCs holds …

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Osteoporosis is a skeletal disorder characterized by a systemic impairment of bone mineral
density (BMD). Genome-wide association studies (GWAS) have identified hundreds of …