Molecular basis for multimerization in the activation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also
generates higher-order multimers, whose nature and function are poorly understood. We …
generates higher-order multimers, whose nature and function are poorly understood. We …
[HTML][HTML] Kinase-mediated quasi-dimers of EGFR
EM Bublil, G Pines, G Patel, G Fruhwirth, T Ng… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Ligand-induced dimerization of the epidermal growth factor receptor (ErbB-1/EGFR)
involves conformational changes that expose an extracellular dimerization interface …
involves conformational changes that expose an extracellular dimerization interface …
Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling
X Yu, KD Sharma, T Takahashi… - Molecular biology of …, 2002 - Am Soc Cell Biol
Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are
the initial and essential events of EGF-induced signal transduction. However, the …
the initial and essential events of EGF-induced signal transduction. However, the …
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor
We study a mechanism by which dimerization of the EGF receptor (EGFR) cytoplasmic
domain is transmitted to the ectodomain. Therapeutic and other small molecule antagonists …
domain is transmitted to the ectodomain. Therapeutic and other small molecule antagonists …
EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
SR Needham, SK Roberts, A Arkhipov… - Nature …, 2016 - nature.com
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor
dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures …
dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures …
Exploring higher-order EGFR oligomerisation and phosphorylation—a combined experimental and theoretical approach
The epidermal growth factor receptor (EGFR) kinase is generally considered to be activated
by either ligand-induced dimerisation or a ligand-induced conformational change within pre …
by either ligand-induced dimerisation or a ligand-induced conformational change within pre …
Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface
JP Dawson, MB Berger, CC Lin… - … and cellular biology, 2005 - Taylor & Francis
Structural studies have shown that ligand-induced epidermal growth factor receptor (EGFR)
dimerization involves major domain rearrangements that expose a critical dimerization arm …
dimerization involves major domain rearrangements that expose a critical dimerization arm …
The EGFR family: not so prototypical receptor tyrosine kinases
MA Lemmon, J Schlessinger… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
(RTKs) for which ligand binding was studied and for which the importance of ligand-induced …
Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is
mutated or overexpressed in several cancers. Despite recent advances, the complex …
mutated or overexpressed in several cancers. Despite recent advances, the complex …
Architecture and membrane interactions of the EGF receptor
Dimerization-driven activation of the intracellular kinase domains of the epidermal growth
factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways …
factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular pathways …