Factor Xa (fXa) is a key enzyme in the coagulation cascade and an essential component of
the prothrombinase complex, which activates prothrombin to thrombin, leading to fibrin clot …

Introduction: Thrombosis is a common causal pathology for stroke, acute coronary syndrome
and venous thromboembolism disorders, which are the leading cause of death worldwide …

Importance of the field. New oral anticoagulants with favorable safety profiles and fixed
doses are required for the management of thromboembolism and stroke prevention in …

Thromboembolic diseases are the leading causes of morbidity and mortality in the
developed world. Anticoagulants provide effective treatment for venous or arterial …

Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …

Thrombosis is a major cause of mortality in the industrialized world. Therefore, the control of
blood coagulation has become a major target for new therapeutic agents. One attractive …

Ischemic heart disease and cerebrovascular disease are the leading causes of death in the
world. Surprisingly, these diseases are treated by relatively antiquated drugs. However, due …

Thrombosis is the underlying cause of a host of common, debilitating, and often fatal
cardiovascular disorders. Formation of thrombi in the arterial circulation can lead to acute …

Thrombosis is a leading cause of death in cardiovascular diseases such as myocardial
infarction (MI), unstable angina and acute coronary syndrome (ACS) in the industrialized …

Coronary heart disease (CHD) is the leading cause of mortality and morbidity in the United
States. Currently, there are approximately 12 million Americans with CHD, which is most …