Abstract The coagulation factor Xa (FXa) plays a central role in the blood coagulation
cascade. Recent studies have shown that FXa is a particularly attractive target for the …

Background To develop superior anticoagulant strategies requires an understanding of the
biochemical and biophysical mechanisms activating and regulating blood coagulation. The …

Introduction: Factor Xa (FXa) is a critical enzyme in the coagulation cascade responsible for
thrombin generation, the final enzyme that leads to fibrin clot formation. Significant success …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

Factor Xa (fXa) is a critical serine protease situated at the confluence of the intrinsic and
extrinsic pathways of the blood coagulation cascade. FXa catalyses the conversion of …

The absence of an adequate reversal strategy to prevent and stop potential life-threatening
bleeding complications is a major drawback to the clinical use of the direct oral inhibitors of …

Factor Xa (FXa) plays a key role in haemostasis, it is a central part of the blood coagulation
cascade which catalyzes the production of thrombin and leads to clot formation and wound …

Due to its critical role in the coagulation cascade Factor Xa became an important target for
antithrombotic drug development. The design of the first generation of Factor Xa inhibitors …

The development of specific inhibitors of blood coagulation enzymes has led to a number of
new anticoagulant/antithrombotic agents that could be useful for prophylaxis and/or …

Factor Xa (FXa) has materialized as a key enzyme for the intervention of the blood
coagulation cascade and for the development of new antithrombotic agents. FXa is the lone …