Neuronal responses to sensory stimuli are not only driven by feedforward sensory pathways
but also depend upon intrinsic factors (collectively known as the network state) that include …

Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural
networks via the release of norepinephrine (NE). However, the exact nature of these …

Chronic recording of locus coeruleus (LC) neurons in rat and monkey have pointed out that
brief, phasic LC discharges, but not sustained activity, are specifically related to salient …

Neurons of the nucleus locus coeruleus (LC) discharge with phasic bursts of activity
superimposed on highly regular tonic discharge rates. Phasic bursts are elicited by bottom …

Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking
have long been perceived as features of global neuromodulation. Recent studies …

Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity
in neuronal networks across the brain, modulating multiple behavioral states. NA release is …

We model spiking neurons in locus coeruleus (LC), a brain nucleus involved in modulating
cognitive performance, and compare with recent experimental data. Extracellular recordings …

Cortical state modulates the background activity of cortical neurons, and their evoked
response to sensory stimulation. Multiple mechanisms are involved in switching between …

The locus coeruleus (LC) noradrenergic (NE) neuromodulatory system is critically involved
in regulation of neural excitability via its diffuse ascending projections. Tonic NE release in …

Cognition fluctuates over relatively faster and slower timescales. This is enabled by dynamic
interactions among cortical neurons over similarly diverse temporal and spatial scales. Fast …