Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history

H Hornsby, AR Nicols, S Longet, C Liu, A Tomic… - Nature …, 2023 - nature.com
Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many
individuals possessing hybrid immunity, generated through a combination of vaccination …

Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine

LL Chen, GT Chua, L Lu, BPC Chan… - Emerging microbes & …, 2022 - Taylor & Francis
ABSTRACT The novel SARS-CoV-2 Omicron variant may increase the risk of re-infection
and vaccine breakthrough infections as it possesses key mutations in the spike protein that …

Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

KK Ariën, L Heyndrickx, J Michiels, K Vereecken… - npj Vaccines, 2022 - nature.com
We report the levels of neutralising antibodies against Wuhan, Delta and Omicron variants in
unimmunized infected (group 1), immunised and boosted (group 2) and infected immunised …

Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination

X Yu, D Wei, W Xu, Y Li, X Li, X Zhang, J Qu, Z Yang… - Cell Discovery, 2022 - nature.com
Dear Editor, As of December, 2021, more than 272 million people have been infected with
SARS-CoV-2. Multiple types of vaccines have been used to build herd immunity for the …

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

T Tada, H Zhou, BM Dcosta, MI Samanovic… - …, 2022 - thelancet.com
Background SARS-CoV-2 vaccines currently authorized for emergency use have been
highly successful in preventing infection and lessening disease severity. The vaccines …

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity

PV Markov, A Katzourakis, NI Stilianakis - Nature Reviews Microbiology, 2022 - nature.com
The comparatively milder infections with the Omicron variant and higher levels of population
immunity have raised hopes for a weakening of the pandemic. We argue that the lower …

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope

P He, B Liu, X Gao, Q Yan, R Pei, J Sun, Q Chen… - Nature …, 2022 - nature.com
Population antibody response is thought to be important in selection of virus variants. We
report that SARS-CoV-2 infection elicits a population immune response that is mediated by a …

SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern

A Aggarwal, AO Stella, G Walker, A Akerman… - medrxiv, 2021 - medrxiv.org
Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have been recorded since January 2020. Over this time global vaccine programs …

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

E Cameroni, JE Bowen, LE Rosen, C Saliba… - Nature, 2022 - nature.com
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …

Breakthrough infections with SARS-CoV-2 Omicron variant despite booster dose of mRNA vaccine

C Kuhlmann, CK Mayer, M Claassen… - Kuhlmann C, Mayer …, 2022 - papers.ssrn.com
Based on its genetic profile and preliminary in vitro and epidemiological data, the recently
emerged SARS-CoV-2 Omicron variant is predicted to evade immune responses to some …