BACKGROUND Ischemic stroke is suggested to be potentially associated with cognitive
impairment in Alzheimer's disease (AD). We hypothesized that cerebral ischemia …

Recent studies suggest that vascular risk factors play a considerable role in the
development of Alzheimer disease. Furthermore, the use of antihypertensive drugs has …

The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and
progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as …

Background The significance of brain angiotensin II in Alzheimer disease (AD) is unclear.
Methods and Results To examine the role of brain angiotensin II in AD …

Angiotensin II type 1 receptor antagonists like losartan have been found to lower the
incidence and progression to Alzheimer's disease (AD), as well as rescue cognitive and …

Background To promote understanding of the pathogenesis of cognitive impairment or
dementia, we explored the potential interaction between transient cerebral ischemia and …

This work was performed to test our hypothesis that angiotensin-(1–7) can ameliorate
cognitive impairment and cerebrovascular reactivity in 5XFAD mice, a useful model of …

The angiotensin receptor blocker losartan mitigated cerebrovascular and cognitive deficits in
mouse models of Alzheimer disease, in line with some clinical evidence of reduced onset …

Hypertension and aging are leading risk factors for stroke and vascular contributions to
cognitive impairment and dementia (VCID). Most animal models fail to capture the complex …

The brain renin‐angiotensin system (RAS) has been highlighted as having a pathological
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …