Cryptococcus neoformans Δsgl1 Vaccination Requires Either CD4+ or CD8+ T Cells for Complete Host Protection

TG Normile, A Rella, M Del Poeta - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Cryptococcus neoformans is a fungal pathogen causing life-threatening
meningoencephalitis in susceptible individuals. Fungal vaccine development has been …

Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1

TG Normile, M Del Poeta - Frontiers in Immunology, 2022 - frontiersin.org
Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines
are currently available in humans mainly because opportunistic mycoses generally occur …

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

AC Colombo, A Rella, T Normile, LS Joffe, PM Tavares… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …

Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development

A Rella, V Mor, AM Farnoud, A Singh… - Frontiers in …, 2015 - frontiersin.org
Cryptococcosis caused by Cryptococcus neoformans and Cryptococcus gattii affects a large
population and is a cause of significant morbidity and mortality. Despite its public health …

[HTML][HTML] Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling

TG Normile, TH Chu, BS Sheridan, M Del Poeta - Mucosal immunology, 2022 - Elsevier
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …

Is Development of a Vaccine against Cryptococcus neoformans Feasible?

CM Leopold Wager, FL Wormley Jr - PLoS pathogens, 2015 - journals.plos.org
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an
encapsulated fungal pathogen that can cause fungal pneumonia and life-threatening …

Glucosylceramide administration as a vaccination strategy in mouse models of cryptococcosis

V Mor, AM Farnoud, A Singh, A Rella, H Tanno, K Ishii… - PloS one, 2016 - journals.plos.org
Cryptococcus neoformans is an opportunistic fungal pathogen and the causative agent of
the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and in …

Innate host defenses against Cryptococcus neoformans

C Hole, FL Wormley - Journal of Microbiology, 2016 - Springer
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause
life-threatening infections of the central nervous system in immunocompromised and …

Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes

MCC Van Dyke, AK Chaturvedi, SE Hardison… - Frontiers in …, 2017 - frontiersin.org
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …

Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans

MM Hester, D Carlson, JK Lodge, SM Levitz… - Frontiers in …, 2024 - frontiersin.org
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over
100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to …