X-ray crystallographic and biochemical investigation of the reaction of cisplatin and
oxaliplatin with nucleosome core particle and naked DNA reveals that histone octamer …

We constructed two site-specifically modified nucleosomes containing an intrastrand cis-{Pt
(NH3) 2} 2+ 1, 3-d (GpTpG) cross-link, similar to one formed by the anticancer drugs …

The binding of the antitumor drug cis-dichlorodiammineplatinum (II) and its inactive trans
isomer with the nucleosome core particle has been investigated. Kinetic studies show that …

The effects of cisplatin binding to DNA were explored at the nucleosome level to incorporate
key features of the eukaryotic nuclear environment. An X-ray crystal structure of a site …

Cisplatin and carboplatin are used successfully to treat various types of cancer. The drugs
target the nucleosomes of cancer cells and form intrastrand DNA cross-links that are located …

Nucleosome positioning and reorganization regulate DNA site exposure in chromatin.
Platinum anticancer agents form DNA adducts that disrupt nuclear activities, triggering …

The mechanism of action of platinum-based anticancer drugs such as cis-
diamminedichloroplatinum (II), or cisplatin, involves three early steps: cell entry, drug …

Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from
severe toxicity and resistance problems, which have not been overcome in spite of decades …

The influence of chromatin structure on cis-diamminedichloroplatinum (II)(cisplatin) DNA
damage was investigated in a reconstituted nucleosome system. Nucleosomes were …

Interstrand cross-linking studies with the antitumor drug cis-diamminedichloroplatinum (II)
and its clinically inactive isomer, trans-diamminedichloroplatinum (II), were performed on a …