Clostridium botulinum C3 is the prototype of C3-like ADP-ribosyltransferases that selectively
ADP-ribosylate the small GTP-binding proteins RhoA/B/C and inhibit their downstream …

Clostridium botulinum adenosine diphosphate (ADP)—ribosyltransferase C3 was the first
bacterial exoenzyme/toxin found to act on small guanosine triphosphate (GTP) ases of the …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …

Various bacterial protein toxins and exoenzymes interfere with target cell functions by
catalyzing posttranslational modification of eukaryoticmaster regulators'. Studies from recent …

The Clostridium botulinum C3 exoenzyme selectively ADP-ribosylates low molecular weight
GTP-binding proteins RhoA, B and C. This covalent modification inhibits Rho signaling …

Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by
ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell …

Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases
that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety …

The Rho family of small GTP-binding proteins functions to regulate the assembly of distinct
actin structures in cells; Rho regulates stress fiber assembly, Rac regulates lamellipodia …

C3 from Clostridium botulinum (C3) specifically modifies Rho GTPases RhoA, RhoB, and
RhoC by mono-ADP-ribosylation. The confined substrate profile of C3 is the basis for its use …

The C3-like ADP-ribosyltransferases exhibit a very confined substrate specificity compared
with other Rho-modifying bacterial toxins; they selectively modify the RhoA,-B, and-C …