Recent advances in our structural understanding of telomerase and telomere-associated
proteins have contributed significantly to elucidating the molecular mechanisms of telomere …

Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation
and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to …

Work in model organisms, such as mouse, yeast, Tetrahymena, ciliates, and plants, has led
to a deeper understanding of telomere biology. Telomeres together with telomere-binding …

In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere
biology. They interact with several other telomere regulators including TIN2, PTOP, POT1 …

Human TIN2 interacts with the telomeric‐DNA‐binding protein TRF1, suppresses telomere
elongation in telomerase‐positive cells, and may control telomere length by modulating …

Human telomeres are bound and protected by protein complexes assembled around the six
core telomeric proteins RAP1, TRF1, TRF2, TIN2, TPP1, and POT1. The function of these …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Telomeres and their associated proteins are specialized structures at the ends of linear
chromosomes that function as caps that protect the DNA from exonuclease degradation and …

Highlights•First cryo-EM structure of telomerase, from Tetrahymena, at∼ 9 Å resolution.•New
TERT and TER domain structures and interactions.•RPA-like proteins bridge the telomerase …

Human telomeres are maintained by the enzyme telomerase, which uses a template within
its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to …