[HTML][HTML] Neuroinflammation, energy and sphingolipid metabolism biomarkers are revealed by metabolic modeling of autistic brains

E Esvap, KO Ulgen - Biomedicines, 2023 - mdpi.com
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
disorders generally characterized by repetitive behaviors and difficulties in communication …

Untargeted metabolomics reveals hepatic metabolic disorder in the BTBR mouse model of autism and the significant role of liver in autism

C Cao, D Wang, M Zou, C Sun… - Cell Biochemistry and …, 2023 - Wiley Online Library
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and the etiology is
unknown. Metabolic dysfunction is present in patients with ASD. In the current study …

Targeted metabolomics highlights perturbed metabolism in the brain of autism spectrum disorder sufferers

SF Graham, O Turkoglu, A Yilmaz, I Ustun, Z Ugur… - Metabolomics, 2020 - Springer
Introduction Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders
characterized by deficiencies in social interactions and communication, combined with …

Untargeted metabolomic analysis reveals the metabolic disturbances and exacerbation of oxidative stress in the cerebral cortex of a BTBR mouse model of Autism

C Cao, Q Li, Y Chen, M Zou, C Sun, X Li… - Journal of Molecular …, 2023 - Springer
The etiology and pathology of autism spectrum disorders (ASDs) are still poorly understood,
which largely limit the treatment and diagnosis of ASDs. Emerging evidence supports that …

[HTML][HTML] A Computational Framework for Studying Gut-Brain Axis in Autism Spectrum Disorder

FK Mohammad, MV Palukuri, S Shivakumar… - Frontiers in …, 2022 - frontiersin.org
Introduction The integrity of the intestinal epithelium is crucial for human health and is
harmed in autism spectrum disorder (ASD). An aberrant gut microbial composition resulting …

Parsing the heterogeneity of brain metabolic disturbances in autism spectrum disorder

J O'Neill, R Bansal, S Goh, M Rodie, S Sawardekar… - Biological …, 2020 - Elsevier
Background Despite rising prevalence of autism spectrum disorder (ASD), its brain bases
remain uncertain. Abnormal levels of N-acetyl compounds, glutamate+ glutamine, creatine+ …

[HTML][HTML] Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

DA Rossignol, RE Frye - Frontiers in physiology, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders that are defined solely on the basis of behavioral observations. Therefore, ASD …

Genome-scale metabolic modelling predicts biomarkers and therapeutic targets for neuropsychiatric disorders

STR Moolamalla, PK Vinod - Computers in Biology and Medicine, 2020 - Elsevier
Distinguishing neuropsychiatric disorders is challenging due to the overlap in symptoms and
genetic risk factors. People suffering from these disorders face personal and professional …

[HTML][HTML] Metabolomic signatures of autism spectrum disorder

D Brister, S Rose, L Delhey, M Tippett, Y Jin… - Journal of Personalized …, 2022 - mdpi.com
Autism Spectrum Disorder (ASD) is associated with many variations in metabolism, but the
ex-act correlates of these metabolic disturbances with behavior and development and their …

[HTML][HTML] Novel systems modeling methodology in comparative microbial metabolomics: identifying key enzymes and metabolites implicated in autism spectrum …

C Heberling, P Dhurjati - International journal of molecular sciences, 2015 - mdpi.com
Autism spectrum disorders are a group of mental illnesses highly correlated with
gastrointestinal dysfunction. Recent studies have shown that there may be one or more …