Although the association between apolipoprotein E (APOE) genotype and disease
progression is well characterized in patients with Alzheimer's disease, such a relationship is …

The relationship between the apolipoprotein E ɛ4 allele (APOE4) and factors associated
with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of …

The presence of apolipoprotein E (APOE) ε4 allele is the only recognized genetic risk factor
for the sporadic form of Alzheimer's disease. The aim of this study was to investigate the …

OBJECTIVE The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for
dementia and Alzheimer's disease (AD), but the underlying mechanism for the increased …

Objective It remains unclear if and how the interactions between APOE genotypes and
cerebral small-vessel diseases (CSVD) lead to cognitive decline in the long term. Based on …

Controversy exists regarding the apolipoprotein E (ApoE) ɛ4 allele association with
vascular dementia (VaD), ranging from increased ɛ4 frequency, similar to that found for …

Objective: To characterize the effects of cerebrovascular (CV) risk factors on preclinical
memory decline in cognitively normal individuals at 3 levels of genetic risk for Alzheimer …

Background Vascular risk factors have been associated with cognitive decline; however, it
remains unclear whether apolipoprotein E (APOE) genotype modifies this relationship. We …

Controversy exists regarding the apolipoprotein E (ApoE) ε4 allele association with vascular
dementia (VaD). The results range from increased ε4 frequency, similar to that found for …

Abstract Introduction Apolipoprotein E (APOE) is a susceptibility gene for late-onset
Alzheimer's disease neuropathology; less is known about the relationship between APOE …