[HTML][HTML] Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer
Background: Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
(PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway …
[HTML][HTML] Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis
Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
[HTML][HTML] Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer
Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …
[HTML][HTML] HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis
Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
[HTML][HTML] Hepatocyte growth factor from a clinical perspective: A pancreatic cancer challenge
W Rizwani, AE Allen, JG Trevino - Cancers, 2015 - mdpi.com
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
and incidence rates are rising. Both detection and treatment options for pancreatic cancer …
[HTML][HTML] Targeting HGF/c-MET axis in pancreatic cancer
Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …
disease that is associated with early metastases. It is characterized by dense and …
The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell–endothelial cell interactions: antiangiogenic implications in pancreatic cancer
MB Patel, SP Pothula, Z Xu, AK Lee… - …, 2014 - academic.oup.com
Activated cancer-associated human pancreatic stellate cells (CAhPSCs, which produce the
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …
Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …
microenvironment and are considered to contribute to chemoresistance. PSCs can …
[HTML][HTML] Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment
The tumor microenvironment plays a key role in tumor development and progression.
Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which …
Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which …
c-Met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth
K Kiehne, KH Herzig, UR Fölsch - Pancreas, 1997 - journals.lww.com
Hepatocyte growth factor (HGF) is a widely expressed growth factor secreted by cells of
mesenchymal origin, which has been shown to be involved in growth processes of multiple …
mesenchymal origin, which has been shown to be involved in growth processes of multiple …