Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and
their interaction with cancer cells facilitates cancer progression. This study investigated the …

Abstract Purpose: The Hedgehog (Hh) pathway has emerged as an important pathway in
multiple tumor types and is thought to be dependent on a paracrine signaling mechanism …

Overexpression and amplification of hepatocyte growth factor (HGF) receptor (Met) have
been detected in many types of human cancers, suggesting a critical role for Met in growth …

Receptor tyrosine kinases have become important therapeutic targets for anti-neoplastic
molecularly targeted therapies. c-Met is a receptor tyrosine kinase shown to be over …

Epithelial-mesenchymal transition (EMT) has recently been studied to elucidate
mechanisms of the liver metastatic process. We investigated EMT in the process of liver …

Hepatocyte growth factor (HGF) is a multifunctional cytokine with important roles in cell
proliferation, survival, motility and morphogenesis. Secreted by cells of mesenchymal origin …

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell
surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

BACKGROUND In prostate cancer, several growth factors derived from stromal cells
regulate tumor cell growth. Hepatocyte growth factor (HGF) possesses biological activities …

The hepatocyte growth factor (HGF): MET axis is a ligand-mediated receptor tyrosine kinase
pathway that is involved in multiple cellular functions, including proliferation, survival …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …