Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Proteins are regulated by an incredible array of posttranslational modifications (PTMs).
Methylation of lysine residues on histone proteins is a PTM with well-established roles in …

Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Histone lysine methylation plays a fundamental role in chromatin organization and function.
This epigenetic mark is involved in many biological processes such as heterochromatin …

The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is …

Dynamic histone lysine methylation involves the activities of modifying enzymes (writers),
enzymes removing modifications (erasers), and readers of the histone code. One common …

Histone methylation is believed to play important roles in epigenetic memory in various
biological processes. However, questions like whether the methylation marks themselves …