Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

The development of metal-based antitumor drugs has been stimulated by the clinical
success of cis-diamminedichloroplatinum (II)(cisplatin) and its analogs and by the clinical …

Platinum anticancer compounds are currently in widespread use for the treatment of
genitourinary and other tumors. In order to understand the mechanism of action of this …

Platinum coordination compounds are among the most utilized anticancer agents, even
though platinum has not been determined to be an essential trace element in any living …

A brief overview is given of platinum anticancer drugs in routine clinical use and under
clinical development worldwide. Details of the binding of these drugs with nucleic acids, the …

This Comment summarises the chemistry and DNA binding of dinuclear platinum-amine, or
bis (platinum), complexes, a new class of potent antitumor agents. In these structures, the Pt …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …

This article reviews investigations over the last 15 years into the development of multi-
nuclear platinum complexes as anti-cancer agents, with the purpose of providing an insight …

Platinum‐based compounds are widely used as chemotherapeutics for the treatment of a
variety of cancers. The anticancer activity of cisplatin and other platinum drugs is believed to …

In recent years there have been numerous major advances in the understanding of the
factors controlling all aspects of platinum binding to DNA and of the consequences of DNA …