Using a model of coronary heart disease incidence based on multivariate logistic regression
functions from the Framingham Heart Study, the cost effectiveness of simvastatin was …

The atmosphere surrounding development of lipid lowering drugs began to change
following publication in JAMA (Jan. 20, 1984) of results from the Lipid Research Clinic …

Numerous studies have demonstrated that treatments designed to reduce low‐density
lipoprotein cholesterol (LDL‐C) can reduce the risk of coronary heart disease (CHD) events …

I recall first learning of the importance of cholesterol from the work of Dr Ancel Keys, based
on his landmark epidemiological studies subsequently identified as the Seven Countries …

Background: Simvastatin and atorvastatin are effective statins for treating
hypercholesterolemia. Hypothesis: The study was undertaken to compare the efficacy and …

This multicenter study compared the effects of lovastatin (40 mg) and pravastatin (40 mg) on
quality of life. Men, aged 20 to 65 years old, with primary hypercholesterolemia (types IIa …

Five centers participated in a double-blind, randomized, active-drug controlled study. The
selected patients had a diagnosis of primary hypercholesterolemia (phenotype Ha or lib …

The costs and benefits of cholesterol lowering in the primary prevention of coronary artery
disease (CAD) were considered using lifetime lovastatin therapy as the intervention model …

The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter
trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose …