The mammalian hearts have the least regenerative capabilities among tissues and organs.
As such, heart regeneration has been and continues to be the ultimate goal in the treatment …

Cardiogenesis, considered as the formation of new heart tissue from embryonic, postnatal,
or adult cardiac progenitors, is a pivotal concept to understand the rationale of advanced …

The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative
medicine. From studies using model organisms, new insights into the fundamental pathways …

Regenerating an injured heart holds great promise for millions of patients suffering from
heart diseases. Since the human heart has very limited regenerative capacity, this is a …

Heart cells are the unitary elements that define cardiac function and disease. The recent
identification of distinct families of cardiovascular progenitor cells begins to build a …

Cell-based regenerative strategies have the potential to revolutionize the way
cardiovascular injury is treated, but successful therapies will require a precise …

Highlights•A plethora of progenitor cells participate in the formation of the human heart.
These cells are derived from the three sources: the mesoderm, the proepicardium and …

The death of cardiac myocytes diminishes the heart's pump function and is a major cause of
heart failure, one of the dominant causes of death worldwide. Other than transplantation …

Despite considerable efforts carried out to develop stem/progenitor cell-based technologies
aiming at replacing and restoring the cardiac tissue following severe damages, thus far no …

The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …