Individual variation in the motivational properties of cocaine
BT Saunders, TE Robinson - Neuropsychopharmacology, 2011 - nature.com
Cues in the environment associated with drug use draw the attention of addicts, elicit
approach, and motivate drug-seeking and drug-taking behavior, making abstinence difficult …
approach, and motivate drug-seeking and drug-taking behavior, making abstinence difficult …
A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction
BT Saunders, TE Robinson - Biological psychiatry, 2010 - Elsevier
BACKGROUND: In addicts drug cues attract attention, elicit approach, and motivate drug-
seeking and drug-taking behavior, and addicts find it difficult to resist such cues. In …
seeking and drug-taking behavior, and addicts find it difficult to resist such cues. In …
A classically conditioned cocaine cue acquires greater control over motivated behavior in rats prone to attribute incentive salience to a food cue
LM Yager, TE Robinson - Psychopharmacology, 2013 - Springer
Rationale Cues associated with rewards bias attention towards them and can motivate drug-
seeking and drug-taking behavior. There is, however, considerable individual variation in …
seeking and drug-taking behavior. There is, however, considerable individual variation in …
A cocaine context renews drug seeking preferentially in a subset of individuals
BT Saunders, EG O'donnell, EL Aurbach… - …, 2014 - nature.com
Addiction is characterized by a high propensity for relapse, in part because cues associated
with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive …
with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive …
Cocaine self‐administration increases the incentive motivational properties of the drug in rats
V Deroche, M Le Moal… - European Journal of …, 1999 - Wiley Online Library
A progressive increase in the frequency and intensity of drug use is one of the major
behavioural phenomena characterizing the development of addiction. The nature of the drug …
behavioural phenomena characterizing the development of addiction. The nature of the drug …
Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer
BJ Tunstall, DN Kearns - Addiction biology, 2016 - Wiley Online Library
The present study aimed to test the hypothesis that cues associated with drug‐taking
behavior become extra strong motivators of behavior compared with cues paired with non …
behavior become extra strong motivators of behavior compared with cues paired with non …
Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats
KH LeBlanc, NT Maidment, SB Ostlund - PloS one, 2013 - journals.plos.org
There is growing evidence that mere exposure to drugs can induce long-term alterations in
the neural systems that mediate reward processing, motivation, and behavioral control …
the neural systems that mediate reward processing, motivation, and behavioral control …
Cocaine-seeking by rats: regulation, reinforcement and activation
MC Olmstead, JA Parkinson, FJ Miles, BJ Everitt… - …, 2000 - Springer
Rationale: In animal models of drug self-administration, response rates often decrease with
dose suggesting that a regulative process may mask the reinforcing effects of the drug …
dose suggesting that a regulative process may mask the reinforcing effects of the drug …
High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats
F Allain, K Bouayad-Gervais, AN Samaha - Psychopharmacology, 2018 - Springer
Rationale Taking high and increasing amounts of cocaine is thought to be necessary for the
development of addiction. Consequently, a widely used animal model of drug self …
development of addiction. Consequently, a widely used animal model of drug self …
Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats
Animal models of human drug abuse measuring (i) cocaine-seeking behavior maintained by
primary or secondary reinforcers,(ii) the time to extinction of cocaine-seeking behavior, and …
primary or secondary reinforcers,(ii) the time to extinction of cocaine-seeking behavior, and …