The neurobiology of cocaine‐induced reinforcement
HC Fibiger, AG Phillips… - … Symposium 166‐Cocaine …, 2007 - Wiley Online Library
Cocaine has potent pharmacological actions on a number of monoaminergic systems in the
brain, including those that use noradrenaline, dopamine and serotonin as neurotransmitters …
brain, including those that use noradrenaline, dopamine and serotonin as neurotransmitters …
Increased motivation for self-administered cocaine after escalated cocaine intake
NE Paterson, A Markou - Neuroreport, 2003 - journals.lww.com
Escalation in cocaine self-administration is hypothesized to involve increased motivation to
consume cocaine. The present study determined the effects of escalated cocaine self …
consume cocaine. The present study determined the effects of escalated cocaine self …
Environmental enrichment counters cocaine abstinence‐induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect
KJ Thiel, MR Painter, NS Pentkowski, D Mitroi… - Addiction …, 2012 - Wiley Online Library
Environmental enrichment (EE) during a period of forced abstinence attenuates incentive
motivational effects of cocaine‐paired stimuli. Here we examined whether EE during forced …
motivational effects of cocaine‐paired stimuli. Here we examined whether EE during forced …
Demand for cocaine and food over time
CJ Christensen, A Silberberg, SR Hursh… - Pharmacology …, 2008 - Elsevier
When reinterpreted, data from Ahmed and Koob [Ahmed, SH, Koob, GF, Transition from
moderate to excessive drug intake: Change in hedonic set point. Science 1998; 282: 298 …
moderate to excessive drug intake: Change in hedonic set point. Science 1998; 282: 298 …
[HTML][HTML] The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors
Rationale Cocaine dependence is characterized by compulsive drug taking that supercedes
other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to …
other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to …
[HTML][HTML] Differential vulnerability to the punishment of cocaine related behaviours: effects of locus of punishment, cocaine taking history and alternative reinforcer …
Background The availability of alternative reinforcement has been shown to reduce drug
use, but it remains unclear whether it facilitates a reduction or cessation of drug seeking or …
use, but it remains unclear whether it facilitates a reduction or cessation of drug seeking or …
Effects of increasing response requirement on choice between cocaine and food in rhesus monkeys
MA Nader, WL Woolverton - Psychopharmacology, 1992 - Springer
Rhesus monkeys were trained in a discretetrials choice procedure and allowed to choose
between intravenous injections of cocaine (0.01–1.0 mg/kg/injection) and food presentation …
between intravenous injections of cocaine (0.01–1.0 mg/kg/injection) and food presentation …
Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
L Canchy, P Girardeau, A Durand… - …, 2021 - nature.com
Cocaine is known to increase brain dopamine at supranormal levels in comparison to
alternative nondrug rewards. According to the dopamine hypothesis of addiction, this …
alternative nondrug rewards. According to the dopamine hypothesis of addiction, this …
The compulsion zone: a pharmacological theory of acquired cocaine self-administration
AB Norman, VL Tsibulsky - Brain research, 2006 - Elsevier
In rats trained to reliably self-administer cocaine, the cumulative drug level was calculated
during sessions in which cocaine was administered either contingently or non-contingently …
during sessions in which cocaine was administered either contingently or non-contingently …
[HTML][HTML] Dissociation of psychomotor sensitization from compulsive cocaine consumption
SH Ahmed, M Cador - Neuropsychopharmacology, 2006 - nature.com
The transition from drug use to drug addiction is associated with a process of escalation,
whereby drug use becomes excessive and difficult to control. Several mechanisms have …
whereby drug use becomes excessive and difficult to control. Several mechanisms have …