Tolerance to the reinforcing effects of cocaine

MW Emmett-Oglesby, JD Lane - Behavioural pharmacology, 1992 - journals.lww.com
This study tested the hypothesis that prolonged exposure to high doses of cocaine would
produce tolerance to the reinforcing effects of cocaine. We determined the rate of …

Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratory

LV Panlilio, S Yasar, R Nemeth-Coslett… - …, 2005 - nature.com
Second-order schedules of drug self-administration were developed to incorporate the
effects of drug-related environmental stimuli into an animal model of drug abuse, making it …

Initiation, maintenance and extinction of cocaine self-administration with and without conditioned reward

R Ranaldi, DCS Roberts - Psychopharmacology, 1996 - Springer
Relapse prevention in abstinent cocaine addicts remains a major focus of drug addiction
therapy. We used a rat model of cocaine addiction that focused on cocaine-seeking …

Shift from goal-directed to habitual cocaine seeking after prolonged experience in rats

A Zapata, VL Minney, TS Shippenberg - Journal of Neuroscience, 2010 - Soc Neuroscience
The development of drug-seeking habits is implicated in the transition from recreational drug
use to addiction. Using a drug seeking/taking chained schedule of intravenous cocaine self …

Influence of an alternative reinforcer on human cocaine self-administration

ST Higgins, WK Bickel, JR Hughes - Life Sciences, 1994 - Elsevier
Identifying factors that modulate cocaine self-administration is fundamental to the
development of effective strategies to treat and prevent cocaine abuse. In the presert study …

A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in rats

M Bongiovanni, RE See - Pharmacology Biochemistry and Behavior, 2008 - Elsevier
Studies on the reinstatement of drug-seeking after withdrawal from chronic drug self-
administration have varied in terms of the procedures by which animals are initially trained …

Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task.

IA Mendez, NW Simon, N Hart, MR Mitchell… - Behavioral …, 2010 - psycnet.apa.org
Cocaine use is associated with high levels of impulsive choice (preference for immediate
over delayed rewards), but it is not clear whether cocaine use causes elevated impulsive …

Impulsive choice as a predictor of acquisition of IV cocaine self-administration and reinstatement of cocaine-seeking behavior in male and female rats.

JL Perry, SE Nelson, ME Carroll - Experimental and clinical …, 2008 - psycnet.apa.org
Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice
predicted the rate of acquisition of IV cocaine self-administration. The objectives of the …

Dissociation between subjective and behavioral responses after cocaine stimuli presentations

SA Dudish-Poulsen, DK Hatsukami - Drug and alcohol dependence, 1997 - Elsevier
This study was designed to explore the relationship between craving and cocaine-seeking
behavior with the use of both subjective and behavioral measures. Five males and five …

Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats

TE Kippin, RA Fuchs, RE See - Psychopharmacology, 2006 - Springer
Rationale Recent evidence suggests that prolonged cocaine self-administration produces
escalation in drug-seeking behavior in rats analogous to the increased intake patterns …