Presenting independently established discriminative stimuli in compound can substantially
increase response rates under food and shock-avoidance schedules. To determine whether …

Having established that the presence of cocaine in a 10%(wt/vol) sucrose solution
enhanced the reinforcing properties of the solution in a dose-dependent manner, the …

Epidemiological research shows that the proportion of drug users who become addicted to
heroin is higher than to cocaine. Here we tested whether this difference could be due to a …

A great deal of research has focused on initiation into drug use and factors that increase the
risk of initiation or protect against it. Initiation into the use of some drugs (such as alcohol) is …

The present study examined the effects of receptor subtype-selective dopamine agonists
and antagonists on (i) cocaine-induced responding for a cocaine-associated stimulus and …

Rationale Agonist medications have been proven effective in treating opioid and nicotine
dependence; results from clinical studies suggest that the indirect dopamine agonist d …

It is important to understand the neural basis of drug-cue conditioning and the mechanisms
that are set into train when an individual is exposed to these cues again, since they drive …

Individual differences in locomotor responses to novelty and psychostimulants, and
sensitization following repeated drug exposure, predict increased sensitivity to the …

A novel behaviorally dependent dosing (BDD) schedule was used to examine the
relationship between doses of cocaine self-administered by rats and brain drug levels within …

Second order schedules of IV cocaine reinforcement in rats provide a reliable method for
evaluating the effects of conditioned stimuli on cocaine-seeking behaviour, and for …