[HTML][HTML] Understanding the redox biology of selenium in the search of targeted cancer therapies

JM Stolwijk, R Garje, JC Sieren, GR Buettner… - Antioxidants, 2020 - mdpi.com
Selenium (Se) is an essential trace nutrient required for optimal human health. It has long
been suggested that selenium has anti-cancer properties. However, clinical trials have …

[HTML][HTML] Selenium in oncology: from chemistry to clinics

O Micke, L Schomburg, J Buentzel, K Kisters… - Molecules, 2009 - mdpi.com
The essential trace element selenium, which is a crucial cofactor in the most important
endogenous antioxidative systems of the human body, is attracting more and more the …

[HTML][HTML] Redox-active selenium compounds—From toxicity and cell death to cancer treatment

S Misra, M Boylan, A Selvam, JE Spallholz… - Nutrients, 2015 - mdpi.com
Selenium is generally known as an antioxidant due to its presence in selenoproteins as
selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly …

Selenium or no selenium-that is the question in tumor patients: a new controversy

R Muecke, L Schomburg, J Buentzel… - Integrative Cancer …, 2010 - journals.sagepub.com
The essential trace element selenium, which is a crucial cofactor in the most important
endogenous antioxidative systems of the human body, is attracting more attention from both …

Selenium and cancer stem cells

G Murdolo, D Bartolini, C Tortoioli, M Piroddi… - Advances in Cancer …, 2017 - Elsevier
Selenium (Se) is an essential micronutrient that functions as “redox gatekeeper” and
homeostasis factor of normal and cancer cells. Epidemiology and experimental studies, in …

[HTML][HTML] Selenium stimulates the antitumour immunity: Insights to future research

A Razaghi, M Poorebrahim, D Sarhan… - European Journal of …, 2021 - Elsevier
Selenium is an essential trace element for regulating immune functions through redox-
regulating activity of selenoproteins (eg glutathione peroxidase), protecting immune cells …

Selenium compounds as therapeutic agents in cancer

AP Fernandes, V Gandin - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background With cancer cells encompassing consistently higher production of reactive
oxygen species (ROS) and with an induced antioxidant defense to counteract the increased …

Selenium and cancer: from prevention to treatment

J Brozmanova - Klinicka onkologie: casopis Ceske a Slovenske …, 2011 - europepmc.org
Selenium (Se) is an essential dietary component for all animals, including human beings,
that is regarded as a protective agent against cancer. Although the mode of its anticancer …

[HTML][HTML] Therapeutic benefits of selenium in hematological malignancies

MA Ehudin, U Golla, D Trivedi, SD Potlakayala… - International journal of …, 2022 - mdpi.com
Supplementing chemotherapy and radiotherapy with selenium has been shown to have
benefits against various cancers. This approach has also been shown to alleviate the side …

Selenium and selenocysteine: roles in cancer, health, and development

DL Hatfield, PA Tsuji, BA Carlson… - Trends in biochemical …, 2014 - cell.com
The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …