Carbapenem resistance determinants acquired through novel chromosomal integrations in extensively drug-resistant Pseudomonas aeruginosa

J Janice, N Agyepong, A Owusu-Ofori… - Antimicrobial agents …, 2021 - Am Soc Microbiol
Two novel bla DIM-1-or bla IMP-1-containing genomic islands (GIs) were discovered by
whole-genome sequence analyses in four extensively drug-resistant (XDR) Pseudomonas …

[HTML][HTML] Spread of Carbapenem Resistance by Transposition and Conjugation Among Pseudomonas aeruginosa

A Van der Zee, WB Kraak, A Burggraaf… - Frontiers in …, 2018 - frontiersin.org
The emergence of carbapenem-resistant Pseudomonas aeruginosa represents a worldwide
problem. To understand the carbapenem-resistance mechanisms and their spreading …

Genomic characterization of Imipenem-and Imipenem-Relebactam-Resistant clinical isolates of pseudomonas aeruginosa

M López-Pérez, JM Haro-Moreno, C Molina-Pardines… - Msphere, 2021 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen and a major cause of
nosocomial infections. The global spread of carbapenem-resistant strains is growing rapidly …

Multilocus sequence typing reveals genetic diversity of carbapenem-or ceftazidime-nonsusceptible Pseudomonas aeruginosa in China

J Ji, J Wang, Z Zhou, H Wang, Y Jiang… - Antimicrobial agents and …, 2013 - Am Soc Microbiol
It is unclear whether the genetic background of drug-resistant Pseudomonas aeruginosa
was disseminated from a certain clone. Thus, we performed MLST (multilocus sequence …

Identification of drug resistance determinants in a clinical isolate of Pseudomonas aeruginosa by high-density transposon mutagenesis

MS Sonnabend, K Klein, S Beier… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
With the aim to identify potential new targets to restore antimicrobial susceptibility of
multidrug-resistant (MDR) Pseudomonas aeruginosa isolates, we generated a high-density …

Characterization of carbapenem-resistant and XDR Pseudomonas aeruginosa in Canada: results of the CANWARD 2007–16 study

MG McCracken, HJ Adam, JM Blondeau… - Journal of …, 2019 - academic.oup.com
Abstract Objectives Carbapenem-resistant Pseudomonas aeruginosa are emerging
worldwide with increasing reports of carbapenemase-producing isolates. Carbapenem …

[HTML][HTML] Genomic characterization of mutli-drug resistant Pseudomonas aeruginosa clinical isolates: evaluation and determination of ceftolozane/tazobactam activity …

I Bitar, T Salloum, G Merhi, J Hrabak, GF Araj… - Frontiers in cellular …, 2022 - frontiersin.org
Resistance to ceftolozane/tazobactam (C/T) in Pseudomonas aeruginosa is a health
concern. In this study, we conducted a whole-genome-based molecular characterization to …

[HTML][HTML] Characterization and Implications of IncP-2A Plasmid pMAS152 Harboring Multidrug Resistance Genes in Extensively Drug-Resistant Pseudomonas …

L Mei, Y Song, X Liu, K Li, X Guo, L Liu, Y Liu… - Microorganisms, 2024 - mdpi.com
Bacterial antimicrobial resistance (AMR) poses a significant global public health challenge.
The escalation of AMR is primarily attributed to the horizontal gene transfer (HGT) of …

Dissemination of high-risk clones of extensively drug-resistant Pseudomonas aeruginosa in Colombia

A Correa, R Del Campo, M Perenguez… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials
represents an important clinical threat worldwide. We report the dissemination in several …

[HTML][HTML] Emergence of Carbapenem Resistance Due to the Novel Insertion Sequence ISPa8 in Pseudomonas aeruginosa

RC Fowler, ND Hanson - PLoS One, 2014 - journals.plos.org
Chronic lung infections due to the persistence of Pseudomonas aeruginosa in cystic fibrosis
patients are typically associated with the emergence of antibiotic resistance. The purpose of …