Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Functional diversity of the highly polymorphic human leukocyte antigen class I (HLA-I) genes
underlies successful immunologic control of both infectious disease and cancer. The …
underlies successful immunologic control of both infectious disease and cancer. The …
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
CD8+ T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …
Strength of immune selection in tumors varies with sex and age
Individual MHC genotype constrains the mutational landscape during tumorigenesis.
Immune checkpoint inhibition reactivates immunity against tumors that escaped immune …
Immune checkpoint inhibition reactivates immunity against tumors that escaped immune …
Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes
DB Graham, C Luo, DJ O'Connell, A Lefkovith… - Nature medicine, 2018 - nature.com
Identifying immunodominant T cell epitopes remains a significant challenge in the context of
infectious disease, autoimmunity, and immuno-oncology. To address the challenge of …
infectious disease, autoimmunity, and immuno-oncology. To address the challenge of …
[PDF][PDF] Germline HLA landscape does not predict efficacy of pembrolizumab monotherapy across solid tumor types
A Chhibber, L Huang, H Zhang, J Xu, R Cristescu… - Immunity, 2022 - cell.com
We evaluated the impact of class I and class II human leukocyte antigen (HLA) genotypes,
heterozygosity, and diversity on the efficacy of pembrolizumab. Seventeen pembrolizumab …
heterozygosity, and diversity on the efficacy of pembrolizumab. Seventeen pembrolizumab …
[HTML][HTML] Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
S Pagliuca, C Gurnari, MT Rubio, V Visconte… - Frontiers in …, 2022 - frontiersin.org
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …
competent adaptive immune responses against pathogen and tumor antigens as it assures …
Advantage of rare HLA supertype in HIV disease progression
The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine
the specificity and repertoire of the immune response. The great diversity of these antigen …
the specificity and repertoire of the immune response. The great diversity of these antigen …
Mutant MHC class II epitopes drive therapeutic immune responses to cancer
Tumour-specific mutations are ideal targets for cancer immunotherapy as they lack
expression in healthy tissues and can potentially be recognized as neo-antigens by the …
expression in healthy tissues and can potentially be recognized as neo-antigens by the …
Lack of detectable neoantigen depletion signals in the untreated cancer genome
Somatic mutations can result in the formation of neoantigens, immunogenic peptides that
are presented on the tumor cell surface by HLA molecules. These mutations are expected to …
are presented on the tumor cell surface by HLA molecules. These mutations are expected to …
Landscape of tumor-infiltrating T cell repertoire of human cancers
We developed a computational method to infer the complementarity-determining region 3
(CDR3) sequences of tumor-infiltrating T cells in 9,142 RNA-seq samples across 29 cancer …
(CDR3) sequences of tumor-infiltrating T cells in 9,142 RNA-seq samples across 29 cancer …