Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported the notion that obesity accelerates AD-related pathophysiology in mouse models …

Objective Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk
factors for developing dementia, and Alzheimer's disease (AD). We hypothesized that a …

Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …

Metabolic dysfunction related to diet‐induced obesity has recently been linked to the
pathogenesis of sporadic Alzheimer's disease (AD). However, the underlying mechanisms …

Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …

Late-onset Alzheimer's disease (LOAD) likely results from combinations of risk factors that
include both genetic predisposition and modifiable lifestyle factors. The E4 allele of …

Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic
factors contribute at what has canonically been considered a centrally mediated process …

This study assessed the extent to which high fat diet (HFD)-induced β-amyloid accumulation
and cognitive decline in APP/PSEN1 mice are reversible through control of fat intake. Ten …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Alzheimer's disease (AD) afflicts an estimated 20 million people worldwide and is the fourth-
leading cause of death in the developed world. The most common cause of dementia in …