The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models
A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …
[HTML][HTML] Concurrence of high fat diet and APOE gene induces allele specific metabolic and mental stress changes in a mouse model of Alzheimer's disease
Y Segev, A Livne, M Mints… - Frontiers in behavioral …, 2016 - frontiersin.org
Aging is the main risk factor for neurodegenerative diseases, including Alzheimer's disease
(AD). However, evidence indicates that the pathological process begins long before actual …
(AD). However, evidence indicates that the pathological process begins long before actual …
[HTML][HTML] Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and …
Diet is a modifiable risk factor for Alzheimer's disease (AD), but the mechanisms linking
alterations in peripheral metabolism and cognition remain unclear. Since it is especially …
alterations in peripheral metabolism and cognition remain unclear. Since it is especially …
Emerging links between nonalcoholic fatty liver disease and neurodegeneration
TJ Kelty, RJ Dashek, WD Arnold… - Seminars in Liver …, 2023 - thieme-connect.com
The association between liver and brain health has gained attention as biomarkers of liver
function have been revealed to predict neurodegeneration. The liver is a central regulator in …
function have been revealed to predict neurodegeneration. The liver is a central regulator in …
Obesity differentially effects the somatosensory cortex and striatum of TgF344-AD rats
M Ahmed, AY Lai, ME Hill, JA Ribeiro, A Amiraslani… - Scientific Reports, 2024 - nature.com
Lifestyle choices leading to obesity, hypertension and diabetes in mid-life contribute directly
to the risk of late-life Alzheimer's disease (AD). However, in late-life or in late-stage AD …
to the risk of late-life Alzheimer's disease (AD). However, in late-life or in late-stage AD …
[HTML][HTML] Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice
HJ Tsay, YL Gan, YH Su, YY Sun, HH Yao… - Biomedicine & …, 2024 - Elsevier
Abstract High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for
Alzheimer's disease (AD). Mitigating fatty liver disease has been shown to attenuate AD-like …
Alzheimer's disease (AD). Mitigating fatty liver disease has been shown to attenuate AD-like …
Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology
S Pedrini, C Thomas, H Brautigam… - Molecular …, 2009 - Springer
Objective Alzheimer's disease (AD) is a progressive neurodegenerative disease of the
central nervous system (CNS). Recently, an increased interest in the role diet plays in the …
central nervous system (CNS). Recently, an increased interest in the role diet plays in the …
Alzheimer's disease: brain expression of a metabolic disorder?
S Merlo, S Spampinato, PL Canonico, A Copani… - Trends in Endocrinology …, 2010 - cell.com
Alzheimer's disease (AD) is the most common form of dementia and is of rapidly increasing
health, social and economic impact. Recent evidence suggests a strict link between …
health, social and economic impact. Recent evidence suggests a strict link between …
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
LM Refolo, MA Pappolla, B Malester, J LaFrancois… - Neurobiology of …, 2000 - Elsevier
Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's
disease (AD). However, no direct evidence has been reported linking cholesterol …
disease (AD). However, no direct evidence has been reported linking cholesterol …
Obesity and hepatic steatosis are associated with elevated serum amyloid beta in metabolically stressed APPswe/PS1dE9 mice
FS Shie, YJ Shiao, CW Yeh, CH Lin, TT Tzeng… - PloS one, 2015 - journals.plos.org
Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease
(AD). For further insights into the underlying mechanisms, we examine whether the genetic …
(AD). For further insights into the underlying mechanisms, we examine whether the genetic …