Prefrontal hypoactivation during working memory in bipolar II depression

JO Brooks, N Vizueta, C Penfold… - Psychological …, 2015 - cambridge.org
Background. Patterns of abnormal neural activation have been observed during working
memory tasks in bipolar I depression, yet the neural changes associated with bipolar II …

Bipolar depressed patients show both failure to activate and failure to de-activate during performance of a working memory task

P Fernández-Corcuera, R Salvador, GC Monté… - Journal of Affective …, 2013 - Elsevier
BACKGROUND: Bipolar depression has been found to be associated with changes in
prefrontal cortex activity during performance of cognitive tasks. However, the role of task …

fMRI abnormalities in dorsolateral prefrontal cortex during a working memory task in manic, euthymic and depressed bipolar subjects

J Townsend, SY Bookheimer, LC Foland–Ross… - Psychiatry Research …, 2010 - Elsevier
Neuropsychological studies of subjects with bipolar disorder suggest impairment of working
memory not only in acute mood states, but also while subjects are euthymic. Using fMRI to …

Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task

CM Adler, SK Holland, V Schmithorst… - Bipolar …, 2004 - Wiley Online Library
Objectives: Several lines of evidence suggest that deficits in cognition persist in bipolar
patients during periods of euthymia. Working memory impairment has been observed in …

Prefrontal activation during a working memory task differs between patients with unipolar and bipolar depression: A preliminary exploratory study

Y Zhu, W Quan, H Wang, Y Ma, J Yan, H Zhang… - Journal of affective …, 2018 - Elsevier
Background To identify bipolar disorder during the initial stages of a depressive episode has
always been a great clinical challenge. Patterns of functional brain activity may underlie the …

Fronto‐temporal dysregulation in remitted bipolar patients: an fMRI delayed‐non‐match‐to‐sample (DNMS) study

JL Robinson, CE Bearden, ES Monkul… - Bipolar …, 2009 - Wiley Online Library
Objectives: Bipolar disorder is associated with working memory (WM) impairments that
persist during periods of symptomatic remission. However, the neural underpinnings of …

Pathological amygdala activation during working memory performance: Evidence for a pathophysiological trait marker in bipolar affective disorder

O Gruber, H Tost, I Henseler, C Schmael… - Human brain …, 2010 - Wiley Online Library
Recent evidence suggests that deficits of working memory may be a promising
neurocognitive endophenotype of bipolar affective disorder. However, little is known about …

Working memory in recurrent brief depression: An fMRI pilot study

MS Korsnes, H Lövdahl, S Andersson… - Journal of affective …, 2013 - Elsevier
BACKGROUND: We examined women with recurrent brief depression (RBD) with and
without episodes of hypomania with an n-back working memory paradigm to assess how …

Brain functional changes across the different phases of bipolar disorder

E Pomarol-Clotet, S Alonso-Lana, N Moro… - The British Journal of …, 2015 - cambridge.org
BackgroundLittle is known about how functional imaging changes in bipolar disorder relate
to different phases of the illness. AimsTo compare cognitive task activation in participants …

Working memory updating in individuals with bipolar and unipolar depression: fMRI study

A Manelis, YO Halchenko, L Bonar, RS Stiffler… - Translational …, 2022 - nature.com
Understanding neurobiological characteristics of cognitive dysfunction in distinct psychiatric
disorders remains challenging. In this secondary data analysis, we examined …