Background Epilepsy is a serious health problem worldwide. Despite the introduction of new
antiepileptic drugs (AEDs) almost 30% of these patients have drug-resistant forms of the …

We aimed to explore the possible influence of CYP2C9 (* 2,* 3 and IVS8-109 A> T),
CYP2C19 (* 2,* 3 and* 17) and ABCB1 (1236C> T, 2677G> A/T and 3435C> T) on …

Abstract Introduction Adverse drug reactions (ADRs) are a major public health concern and
a leading cause of morbidity and mortality in the world. In the case of antiepileptic drugs …

Background and purpose: It is widely acknowledged that individual response to antiepileptic
drugs (AEDs) is influenced by genetic factors. However, most of the underlying genes and …

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism
observed in the corresponding gene may affect therapeutic outcome during treatment. The …

Background Genetic polymorphisms are known to influence outcomes with phenytoin yet
effects in the Middle East and North Africa region are poorly understood. Objectives The …

This work was performed to explore the effect of polymorphism in multidrug resistant genes
on plasma phenytoin levels and patient outcome to evaluate its involvement in drug …

Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …

Background: The first-line antiepileptic drugs, although affordable and effective in the control
of seizures, are associated with adverse drug effects, and there is large interindividual …