Insulin therapy development beyond 100 years

PD Home, R Mehta - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
The first insulin preparation capable of consistently lowering blood glucose was developed
in 1921. But 100 years later, blood glucose control with insulin in people with diabetes is …

Insulins today and beyond

DR Owens, B Zinman, GB Bolli - The Lancet, 2001 - thelancet.com
The advent of insulin almost 80 years ago revolutionised treatment of diabetes and must be
one of the most outstanding achievements of twentieth century medicine. Since then, there …

New forms of insulin and insulin therapies for the treatment of type 2 diabetes

A Cahn, R Miccoli, A Dardano… - The Lancet Diabetes & …, 2015 - thelancet.com
Insulin is a common treatment option for many patients with type 2 diabetes, and is generally
used late in the natural history of the disease. Its injectable delivery mode, propensity for …

Insulin analogues

AH Barnett, DR Owens - The Lancet, 1997 - thelancet.com
The first long-acting analogue was the acidic soluble NovoSol Basal with substantially
slower absorption than human ultralente insulin, because it microcrystallises immediately …

Strategies to improve the affordability of insulin in the USA

J Luo, AS Kesselheim, J Greene… - The Lancet Diabetes & …, 2017 - thelancet.com
Global challenges regarding access to insulin have been documented in low-income and
middle-income countries, 1 but high-income countries are not exempt from these problems …

Implantable insulin pumps: an effective option with restricted dissemination

NA Spaan, AE Teplova, E Renard… - The Lancet Diabetes & …, 2014 - thelancet.com
At present, continuous subcutaneous insulin infusion from portable pumps with fast-acting
insulin analogues is considered a reference method of treatment for type 1 diabetes …

Insulin therapies–past, present and future

O Pillai, R Panchagnula - Drug discovery today, 2001 - Elsevier
The discovery of insulin is one of the greatest milestones in medical history. This discovery
revolutionized the use of peptides and proteins as therapeutic agents. For more than six …

On the road to the insulin centenary

D Beran, M Basey, V Wirtz, W Kaplan, M Atkinson… - The Lancet, 2012 - thelancet.com
World Diabetes Day, Nov 14, celebrates and raises awareness about diabetes on a global
level. In the 90 years since the first person received insulin, this medical miracle has saved …

New horizons—alternative routes for insulin therapy

DR Owens - Nature Reviews Drug Discovery, 2002 - nature.com
Since the introduction of insulin therapy 80 years ago, the lives of millions of patients with
diabetes have been saved, prolonged and immeasurably improved. However, restoring …

Insulin: a new era for an old hormone

V Sabetsky, J Ekblom - Pharmacological Research, 2010 - Elsevier
All forms of diabetes have been treatable since insulin became medically available in 1921.
While insulin alone produces a substantial reduction in blood-glucose levels and is thus the …