Resistance to antimalarials: a pharmacogenomics approach for both parasite and human host
L Pernaute-Lau - 2022 - repositorio.ul.pt
Malaria is a vector-borne disease that affected up to 241 million people just last year,
causing more than 602 thousand deaths in Africa alone. Global strategies for malaria control …
causing more than 602 thousand deaths in Africa alone. Global strategies for malaria control …
Genomic approaches to drug resistance in malaria
F Rocamora, EA Winzeler - Annual Review of Microbiology, 2020 - annualreviews.org
Although the last two decades have seen a substantial decline in malaria incidence and
mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy …
mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy …
Pharmacogene sequencing of a gabonese population with severe plasmodium falciparum malaria reveals multiple novel variants with putative relevance for …
L Pernaute-Lau, AA Adegnika, Y Zhou… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Malaria remains one of the deadliest diseases in Africa, particularly for children. While
successful in reducing morbidity and mortality, antimalarial treatments are also a major …
successful in reducing morbidity and mortality, antimalarial treatments are also a major …
[HTML][HTML] Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum
J Oberstaller, L Zoungrana, CD Bannerman… - International Journal for …, 2021 - Elsevier
Resistance to antimalarial drugs, and in particular to the artemisinin derivatives and their
partner drugs, threatens recent progress toward regional malaria elimination and eventual …
partner drugs, threatens recent progress toward regional malaria elimination and eventual …
[PDF][PDF] Antimalarial Drug Resistance in Africa: Current Status and Future Prospects
EU Usoro, MA Akintola, MO Buari, NC Dike, AI Owulu… - ijscia.com
Malaria remains a significant public health concern in Africa, with millions of cases reported
annually. However, the effectiveness of antimalarial drugs, a cornerstone of malaria control …
annually. However, the effectiveness of antimalarial drugs, a cornerstone of malaria control …
Changing molecular markers of antimalarial drug sensitivity across Uganda
The potential spread of antimalarial drug resistance to Africa, in particular for artemisinins
and key partner drugs, is a major concern. We surveyed Plasmodium falciparum genetic …
and key partner drugs, is a major concern. We surveyed Plasmodium falciparum genetic …
Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy
RK Mehlotra, CN Henry-Halldin, PA Zimmerman - 2009 - Future Medicine
Drug resistance in malaria jeopardizes the most elementary objectives of malaria control–
reducing suffering and eliminating mortality. An important, and so far the only known …
reducing suffering and eliminating mortality. An important, and so far the only known …
Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance
JM Mwangi, LC Ranford-Cartwright - Parasitology, 2013 - cambridge.org
The biggest threat to the war on malaria is the continued evolution of drug resistance by the
parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium …
parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium …
[HTML][HTML] Assessing the roles of molecular markers of antimalarial drug resistance and the host pharmacogenetics in drug-resistant malaria
P Hodoameda, NO Duah-Quashie… - Journal of Tropical …, 2022 - hindawi.com
Malaria caused by the Plasmodium parasites is a major public health concern in malaria-
endemic regions with P. falciparum causing the most severe form of the disease. The use of …
endemic regions with P. falciparum causing the most severe form of the disease. The use of …
Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border
Drug resistance has emerged as one of the greatest challenges facing malaria control. The
recent emergence of resistance to artemisinin (ART) and its partner drugs in ART-based …
recent emergence of resistance to artemisinin (ART) and its partner drugs in ART-based …