Regular physical exercise has emerged, together with dietary restriction, as an effective
intervention in delaying degenerative diseases and augmenting life span in rodents. The …

Unlike calorie restriction, exercise fails to extend maximum life span, but the mechanisms
that explain this disparate effect are unknown. We used a 24-wk protocol of treadmill …

Aging is associated with declining exercise and unhealthy changes in body composition.
Exercise ameliorates certain adverse age‐related physiological changes and protects …

The importance of maintaining physical fitness by engaging in exercise in a life-long
perspective as well as the avoidance of obesity has been emphasised in recent years by …

Exercise and caloric restriction improve skeletal muscle metabolism. However, the benefits
of exercise and caloric restriction on skeletal muscle metabolism in aging have never been …

We investigated the effects of ageing, exercise and food restriction on glucose uptake by
muscles perfused with physiological concentrations of insulin and glucose in male Long …

Calorie restriction (CR) slows aging and is thought to improve insulin sensitivity in laboratory
animals. In contrast, decreased insulin signaling and/or mild insulin resistance paradoxically …

Physical exercise is the most effective intervention against sarcopenia of aging; however,
the cellular and molecular mechanisms mediating training-induced adaptations are not yet …

We previously showed that 7 wk of treadmill exercise training in late-middle-aged rats can
reverse the modest reductions in skeletal muscle aerobic function and enzyme activity …

Laboratory rats are normally confined to cages that markedly restrict their physical activity. In
these rats, the resting energy expenditure accounts for 90% of the total daily energy …