Abstract Purpose of Review Poor treatment response is a hallmark of major depressive
disorder. To tackle this problem, recent neuroimaging studies have sought to characterize …

Although major depressive disorder (MDD) is associated with altered functional coupling
between disparate neural networks, the degree to which such measures are ameliorated by …

Importance Despite the widespread awareness of functional magnetic resonance imaging
findings suggesting a role for cortical connectivity networks in treatment selection for major …

Objective: Despite significant advances in neuroscience and treatment development, no
widely accepted biomarkers are available to inform diagnostics or identify preferred …

Default mode network (DMN) dysfunction (particularly within the anterior cingulate cortex
(ACC) and medial prefrontal cortex (mPFC)) has been implicated in major depressive …

Background Current practice for selecting pharmacological and non-pharmacological
antidepressant treatments has yielded low response and remission rates in Major …

Objective: Major depressive disorder is associated with aberrant resting-state functional
connectivity across multiple brain networks supporting emotion processing, executive …

Background Major depressive disorder (MDD) is a highly heterogeneous disorder that
typically emerges in adolescence and can occur throughout adulthood. Studies aimed at …

Conventional monoamine-based pharmacotherapy, considered the first-line treatment for
major depressive disorder (MDD), has several challenges, including high rates of non …

Background In treating major depressive disorder, we lack tests anchored in neurobiology
that predict antidepressant efficacy. Cognitive impairments are a particularly disabling …