Introduction to microelectrode arrays, the site-selective functionalization of electrode surfaces, and the real-time detection of binding events

MD Graaf, KD Moeller - Langmuir, 2015 - ACS Publications
Microelectrode arrays have great potential as analytical tools because currents can be
independently measured at each electrode in the array. In principle, these currents can be …

Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

K Drayton-White, S Liu, YC Chang… - Beilstein Journal of …, 2022 - beilstein-journals.org
Microelectrode arrays are powerful tools for monitoring binding interactions between small
molecules and biological targets. In most cases, molecules to be studied using such devices …

A new porous reaction layer for developing addressable molecular libraries

L Hu, JL Bartels, JW Bartels, K Maurer… - Journal of the …, 2009 - ACS Publications
A new diblock copolymer-derived porous reaction layer for microelectrode arrays has been
tested for its stability and its compatibility with both site-selective synthesis and …

[PDF][PDF] Site-selective immobilization of ligands with control of density on electroactive microelectrode arrays

EWL Chan, MN Yousaf - ChemPhysChem, 2007 - academia.edu
A microelectrode array (MEA) is an arrangement of several separate electrodes that permits
site-selective detection and modulation of an electrical signal. The conventional uses of …

Electroorganic synthesis and the construction of addressable molecular surfaces

NH Yeh, Y Zhu, KD Moeller - ChemElectroChem, 2019 - Wiley Online Library
In this Minireview, an electroorganic synthesis approach to the construction of addressable,
complex molecular surfaces is described along with the parameters that guided the …

From molecules to molecular surfaces. Exploiting the interplay between organic synthesis and electrochemistry

Q Jing, KD Moeller - Accounts of chemical research, 2019 - ACS Publications
Conspectus For many years, we have been looking at electrochemistry as a tool for
exploring, developing, and implementing new synthetic methods for the construction of …

Organic electrochemistry and a role reversal: using synthesis to optimize electrochemical methods

NH Yeh, M Medcalf, KD Moeller - Journal of the American …, 2018 - ACS Publications
Diblock copolymers are excellent coatings for microelectrode arrays because they provide a
stable surface that can support both synthetic and analytical electrochemistry. However, the …

Building addressable libraries: Amino acid derived fluorescent linkers

T Tanabe, B Bi, L Hu, K Maurer, KD Moeller - Langmuir, 2012 - ACS Publications
A new amino acid derived fluorescent linker for attaching molecules to the surface of a
microelectrode array has been developed. Molecules to be monitored on an array are …

The use of a detectable, mass-spectrometry-cleavable linker for quality control on an addressable microelectrode array

C Chen, P Lu, A Walker, K Maurer… - Electrochemistry …, 2008 - Elsevier
The synthesis, site-selective placement, and TOF-SIMS cleavage properties of a new,
fluorescent linker for attaching molecules to a microelectrode array are reported. The linker …

Electropolymerization on microelectrodes: functionalization technique for selective protein and DNA conjugation

E Stern, S Jay, J Bertram, B Boese… - Analytical …, 2006 - ACS Publications
A critical shortcoming of current surface functionalization schemes is their inability to
selectively coat patterned substrates at micrometer and nanometer scales. This limitation …