Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment

B Knoppova, C Reily, RG King, BA Julian… - Journal of clinical …, 2021 - mdpi.com
IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …

New insights into the pathogenesis of IgA nephropathy

J Novak, D Rizk, K Takahashi, XW Zhang, Q Bian… - Kidney …, 2015 - karger.com
Background: IgA nephropathy, a frequent cause of end-stage renal disease, is an
autoimmune disease wherein immune complexes consisting of IgA1 with galactose-deficient …

Aberrant glycosylation of the IgA1 molecule in IgA nephropathy

J Novak, J Barratt, BA Julian, MB Renfrow - Seminars in nephrology, 2018 - Elsevier
IgA nephropathy, the most common primary glomerulonephritis in the world and a frequent
cause of end-stage renal disease, is characterized by typical mesangial deposits of IgA1, as …

Primary IgA nephropathy: new insights into pathogenesis

J Barratt, J Feehally - Seminars in Nephrology, 2011 - Elsevier
Since its first description more than 40 years ago, IgA nephropathy has become the most
common pattern of primary glomerulonephritis identified in all areas of the world where renal …

Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathy

WJ Placzek, H Yanagawa, Y Makita, MB Renfrow… - PLoS …, 2018 - journals.plos.org
IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular
immune deposits. We previously proposed a multi-hit pathogenesis model in which patients …

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

J Novak, BA Julian, J Mestecky, MB Renfrow - Seminars in …, 2012 - Springer
IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune
disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the …

Cellular signaling and production of galactose‐deficient IgA1 in IgA nephropathy, an autoimmune disease

C Reily, H Ueda, ZQ Huang, J Mestecky… - Journal of …, 2014 - Wiley Online Library
Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary
glomerulonephritis, is characterized by IgA1‐containing immunodeposits in the glomeruli …

Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity

H Suzuki, R Fan, Z Zhang, R Brown… - The Journal of …, 2009 - Am Soc Clin Investig
IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of
galactose-deficient IgA1 and a glycan-specific IgG antibody. These immune complexes …

IgA nephropathy enigma

J Mestecky, J Novak, Z Moldoveanu, M Raska - Clinical Immunology, 2016 - Elsevier
IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis in the world. The
disease is characterized by the presence of IgA-containing immune complexes in the …

Glomerular immunodeposits of patients with IgA nephropathy are enriched for IgG autoantibodies specific for galactose-deficient IgA1

DV Rizk, MK Saha, S Hall, L Novak… - Journal of the …, 2019 - journals.lww.com
Background IgA nephropathy (IgAN) is the leading primary GN worldwide. The disease is
thought to result from glomerular deposition of circulating immune complexes of IgG bound …