Repeated immune activation with low-dose lipopolysaccharide attenuates the severity of Huntington's disease in R6/2 transgenic mice
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the
huntingtin gene. Previously, therapeutic approaches using anti-inflammatory agents were …
huntingtin gene. Previously, therapeutic approaches using anti-inflammatory agents were …
[HTML][HTML] iNKT cell activation exacerbates the development of Huntington's disease in R6/2 transgenic mice
Huntington's disease (HD) is an inherited neurodegenerative disorder which is caused by a
mutation of the huntingtin (HTT) gene. Although the pathogenesis of HD has been …
mutation of the huntingtin (HTT) gene. Although the pathogenesis of HD has been …
A novel Huntington's disease mouse model to assess the role of neuroinflammation on disease progression and to develop human cell therapies
H Dahlenburg, D Cameron, S Yang… - Stem cells …, 2021 - academic.oup.com
Huntington's disease (HD) is a fatal autosomal-dominant neurodegenerative disease
caused by a trinucleotide CAG repeat expansion of the huntingtin gene (HTT) that affects 1 …
caused by a trinucleotide CAG repeat expansion of the huntingtin gene (HTT) that affects 1 …
Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington's disease by etanercept treatment
J Pido-Lopez, B Tanudjojo, S Farag, MK Bondulich… - Scientific Reports, 2019 - nature.com
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the
expansion of the CAG repeat in exon 1 of the huntingtin (HTT) gene, which results in a …
expansion of the CAG repeat in exon 1 of the huntingtin (HTT) gene, which results in a …
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease
HY Hsiao, FL Chiu, CM Chen, YR Wu… - Human molecular …, 2014 - academic.oup.com
Neuroinflammation is a common feature of many neurodegenerative diseases, including
Huntington's disease (HD). HD is an autosomal dominant genetic disease caused by an …
Huntington's disease (HD). HD is an autosomal dominant genetic disease caused by an …
[HTML][HTML] Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models
U Träger, R Andre, A Magnusson-Lind, JRC Miller… - Neurobiology of …, 2015 - Elsevier
Inflammation is a growing area of research in neurodegeneration. In Huntington's disease
(HD), a fatal inherited neurodegenerative disease caused by a CAG-repeat expansion in the …
(HD), a fatal inherited neurodegenerative disease caused by a CAG-repeat expansion in the …
[PDF][PDF] Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice
K Griffioen, MP Mattson, E Okun - Heliyon, 2018 - cell.com
Abstract Huntington's disease (HD), an autosomal dominant neurodegenerative disorder
characterized by progressive striatal and cortical atrophy, has been strongly linked with …
characterized by progressive striatal and cortical atrophy, has been strongly linked with …
[HTML][HTML] Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics
Q Jia, S Li, XJ Li, P Yin - Frontiers in Immunology, 2022 - frontiersin.org
Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …
Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant …
S Liu, X Yu, J Zhu, X Liu, Y Zhang, Q Dong, S Ma, R Liu - Brain Research, 2018 - Elsevier
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by
progressive movement disorders and cognitive deficits, which is caused by a CAG-repeat …
progressive movement disorders and cognitive deficits, which is caused by a CAG-repeat …
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both
neurological and systemic abnormalities. We examined the peripheral immune system and …
neurological and systemic abnormalities. We examined the peripheral immune system and …