[HTML][HTML] Innate invariant NKT cell recognition of HIV-1–infected dendritic cells is an early detection mechanism targeted by viral immune evasion

D Paquin-Proulx, A Gibbs, SM Bächle… - The Journal of …, 2016 - journals.aai.org
Invariant NKT (iNKT) cells are innate-like T cells that respond rapidly with a broad range of
effector functions upon recognition of glycolipid Ags presented by CD1d. HIV-1 carries Nef …

Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection

G Alter, M Altfeld - Trends in immunology, 2011 - cell.com
Accumulating data suggest that natural killer (NK) cells are involved not only in the innate
antiviral response following infection, but also in shaping the quality of the adaptive immune …

DCs and NK cells: critical effectors in the immune response to HIV-1

M Altfeld, L Fadda, D Frleta, N Bhardwaj - Nature Reviews Immunology, 2011 - nature.com
Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by
shaping the quality of the adaptive immune response to viruses and by mediating direct …

Innate immune control of HIV

M Carrington, G Alter - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Mounting evidence suggests a role for innate immunity in the early control of HIV infection,
before the induction of adaptive immune responses. Among the early innate immune effector …

[HTML][HTML] Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in …

E Shinya, M Shimizu, A Owaki, S Paoletti, L Mori… - Virology, 2016 - Elsevier
Dendritic cells (DCs) play a major role in in vivo pathogenesis of HIV-1 infection. Therefore,
DCs may provide a promising strategy to control and eventually overcome the fatal infection …

[HTML][HTML] Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

MC Costanzo, D Kim, M Creegan, KG Lal… - Nature …, 2018 - nature.com
Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-
dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence …

[HTML][HTML] Exploring the therapeutic potentials of iNKT cells for anti-HBV treatment

A Lawrenczyk, S Kim, X Wen, R Xiong, W Yuan - Pathogens, 2014 - mdpi.com
CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that
recognize lipid antigens. Both mouse modeling experiments and human clinical studies …

CD4+ T-Cell Help Enhances NK Cell Function following Therapeutic HIV-1 Vaccination

S Jost, PJ Tomezsko, K Rands, I Toth… - Journal of …, 2014 - Am Soc Microbiol
Increasing data suggest that NK cells can mediate antiviral activity in HIV-1-infected
humans, and as such, novel approaches harnessing the anti-HIV-1 function of both T cells …

NKT cell immune responses to viral infection

MS Tessmer, A Fatima, C Paget, F Trottein… - Expert opinion on …, 2009 - Taylor & Francis
Background: Natural killer T (NKT) cells are a heterogeneous population of innate T cells
that have attracted interest because of their potential to regulate immune responses to a …

[HTML][HTML] Hiding lipid presentation: viral interference with CD1d-restricted invariant natural killer T (iNKT) cell activation

D Horst, RJ Geerdink, AM Gram, AJ Stoppelenburg… - Viruses, 2012 - mdpi.com
The immune system plays a major role in protecting the host against viral infection. Rapid
initial protection is conveyed by innate immune cells, while adaptive immunity (including T …