The replication of human immunodeficiency type-1 (HIV-1) is restricted in macaque cells, in
part due to host factors that provide intrinsic immunity after entry. Here we show that a …

Background The TRIM5α protein is a principal restriction factor that contributes to an HIV-1
replication block in rhesus macaque CD4+ T cells by preventing reverse transcription. HIV-1 …

The expression of xenogeneic TRIM5α proteins can restrict infection in various
retrovirus/host cell pairings. Previously, we have shown that African green monkey TRIM5α …

HIV-1 infection is restricted at a post-entry stage in some simian cell lines by species-specific
variants of TRIM5α. Restriction targets the viral capsid protein (CA) and results in attenuated …

Tripartite motif-containing protein 5α (TRIM5α) is considered to be a potential target for cell-
based gene modification therapy against human immunodeficiency virus type 1 (HIV-1) …

Tripartite motif-containing 5 isoform-α (TRIM5α), a host restriction factor, blocks infection of
some retroviruses at a post-entry, pre-integration stage in a species-specific manner. A …

Human immunodeficiency virus type 1 (HIV-1) efficiently enters cells of Old World monkeys
but encounters a block before reverse transcription. This restriction is mediated by a …

Rhesus TRIM5α (rhTRIM5α), but not human TRIM5α (huTRIM5α), potently inhibits human
immunodeficiency virus (HIV) infection and is thus a potentially valuable therapeutic tool …

The host restriction factor TRIM5α provides intrinsic defense against retroviral infections in
mammalian cells. TRIM5α blocks infection by targeting the viral capsid after entry but prior to …

Species-specific innate resistance against viral infections offers novel avenues for antiviral
therapeutic and prophylactic approaches. The retroviral and lentiviral restriction factors Ref1 …