Modulation of host immune responses following non-hematopoietic stem cell transplantation: Translational implications in progressive multiple sclerosis

G Volpe, JD Bernstock, L Peruzzotti-Jametti… - Journal of …, 2019 - Elsevier
There exists an urgent need for effective treatments for those patients suffering from
chronic/progressive multiple sclerosis (MS). Accordingly, it has become readily apparent that …

Hematopoietic stem cell transplantation for multiple sclerosis: is it a clinical reality?

MM Bakhuraysah, C Siatskas, S Petratos - Stem Cell Research & Therapy, 2016 - Springer
Hematopoietic stem cell transplantation (HSCT) is a treatment paradigm that has long been
utilized for cancers of the blood and bone marrow but has gained some traction as a …

[HTML][HTML] The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies

R Meamar, S Nematollahi, L Dehghani… - Advanced biomedical …, 2016 - journals.lww.com
The complexity of multiple sclerosis (MS) and the incompetence of a large number of
promised treatments for MS urge us to plan new and more effective therapeutic approaches …

Stem cell therapies for progressive multiple sclerosis

JA Smith, AM Nicaise, RB Ionescu, R Hamel… - Frontiers in cell and …, 2021 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterized by demyelination and axonal degeneration. MS patients typically present with …

Stem cell therapy for multiple sclerosis: preclinical evidence beyond all doubt?

K Reekmans, J Praet, N De Vocht, J Daans… - Regenerative …, 2012 - Taylor & Francis
Stem cell transplantation holds great promise for restoration of neural function in various
neurodegenerative disorders, including multiple sclerosis (MS). However, many questions …

Autologous and allogeneic hematopoietic stem cell transplantation for multiple sclerosis: perspective on mechanisms of action

B Van Wijmeersch, B Sprangers, B Dubois… - Journal of …, 2008 - Elsevier
Multiple Sclerosis (MS) is a frequent demyelinating immune-mediated disease of the central
nervous system (CNS) that affects principally young adults and leads to severe physical and …

Immunological questions on hematopoietic stem cell transplantation for multiple sclerosis

PA Muraro, R Martin - Bone marrow transplantation, 2003 - nature.com
Multiple sclerosis (MS) is considered an inflammatory autoimmune disorder. Approved
immunotherapies are only moderately effective in reducing disease exacerbations and brain …

Various strategies to improve efficacy of stem cell transplantation in multiple sclerosis: focus on mesenchymal stem cells and neuroprotection

F Yousefi, FL Arab, K Saeidi, H Amiri… - Journal of …, 2019 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which predominantly affect young adults and undergo heavy socioeconomic …

Promises and limitations of neural stem cell therapies for progressive multiple sclerosis

S Pluchino, JA Smith, L Peruzzotti-Jametti - Trends in Molecular Medicine, 2020 - cell.com
Multiple disease-modifying medications with regulatory approval to treat multiple sclerosis
(MS) are unable to prevent inflammatory tissue damage in the central nervous system …

[HTML][HTML] The Role of Mesenchymal Stem Cells in Modulating Adaptive Immune Responses in Multiple Sclerosis

S Dadfar, E Yazdanpanah, A Pazoki, MH Nemati… - Cells, 2024 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system,
leading to significant disability through neurodegeneration. Despite advances in the …