Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond

D Van Nguyen, C Vidal, HC Chu… - Asia Pacific Allergy, 2019 - journals.lww.com
Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in
a very great burden of disease. These reactions not only carry with them a high mortality …

Severe drug hypersensitivity reactions: clinical pattern, diagnosis, etiology and therapeutic options

M Paulmann, M Mockenhaupt - Current Pharmaceutical …, 2016 - ingentaconnect.com
Severe cutaneous adverse reactions (SCAR) are known for a high morbidity and mortality.
They may be life-threatening for the affected patient and difficult to accomplish for the …

Approach to severe cutaneous adverse drug reactions

T Bellón, R Cabañas, C González-Herrada… - … Treatment Options in …, 2017 - Springer
Opinion Statement Severe cutaneous adverse drug reactions (SCARs) can occur at any age
and can be life threatening, although some drugs have been more frequently reported than …

Recognition and management of severe cutaneous adverse drug reactions (including drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson …

CE Owen, JM Jones - Medical Clinics, 2021 - medical.theclinics.com
Severe cutaneous adverse reactions to medications (SCARs) are dose-dependent
manifestations of hypersensitivity phenotypes. Drug reaction with eosinophilia and systemic …

Clinical phenotypes of severe cutaneous drug hypersensitivity reactions

H Guvenir, T Arikoglu, E Vezir… - Current Pharmaceutical …, 2019 - ingentaconnect.com
Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most
drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever …

Drug-induced severe cutaneous adverse reactions: Determine the cause and prevention

C Zhang, DN Van, C Hieu, T Craig - Annals of Allergy, Asthma & …, 2019 - Elsevier
Background Approximately 45% of all adverse drug reactions are manifested in the skin.
Although most are mild, severe cutaneous adverse reactions (SCARs) are potentially lethal …

Severe cutaneous adverse drug reactions: presentation, risk factors, and management

SS Mustafa, D Ostrov, D Yerly - Current allergy and asthma reports, 2018 - Springer
Abstract Purpose of Study Immune-mediated adverse drug reactions occur commonly in
clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated …

Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions

A Gibson, P Deshpande, CN Campbell… - Journal of allergy and …, 2023 - Elsevier
Severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome, toxic
epidermal necrolysis (SJS/TEN), and drug reaction with eosinophilia and systemic …

Epidemiology and causes of severe cutaneous adverse reactions to drugs

M Mockenhaupt - Drug hypersensitivity, 2007 - karger.com
Toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized
exanthematous pustulosis (AGEP) and hypersensitivity syndrome (HSS), which is also …

[HTML][HTML] Drug-induced severe cutaneous adverse reactions: insights into clinical presentation, immunopathogenesis, diagnostic methods, treatment, and …

T Tempark, S John, P Rerknimitr… - Frontiers in …, 2022 - frontiersin.org
SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased
duration of hospital stays and the associated cost burden are common issues, and in the …