The gut–kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition

R Coppo - Pediatric nephrology, 2018 - Springer
Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the
development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association …

The gut-renal connection in IgA nephropathy

R Coppo - Seminars in nephrology, 2018 - Elsevier
The connection between a dysregulated gut-associated lymphoid tissue and IgA
nephropathy (IgAN) was supposed decades ago after the observation of increased …

The intestine–renal connection in IgA nephropathy

R Coppo - Nephrology Dialysis Transplantation, 2015 - academic.oup.com
It is commonly stated that mucosal immunity plays a role in the pathogenesis of IgA
nephropathy (IgAN); however, the search for specific eliciting factors has been largely …

Role of IgA receptors in the pathogenesis of IgA nephropathy

SM Lechner, C Papista, JM Chemouny, L Berthelot… - Journal of …, 2016 - Springer
Immunoglobulin A nephropathy (IgAN) or Berger's disease is the most common form of
primary glomerulonephritis in the world and one of the first causes of end-stage renal failure …

The mucosa–kidney axis in IgA nephropathy

J Floege, J Feehally - Nature Reviews Nephrology, 2016 - nature.com
Abstract Links between IgA nephropathy (IgAN) and the mucosa have been recognized
since the 1970s. In particular, the observation of visible haematuria induced by respiratory …

Aberrant Gut Microbiome Contributes to Barrier Dysfunction, Inflammation, and Local Immune Responses in IgA Nephropathy

Y Tang, Y Xiao, H He, Y Zhu, W Sun, P Hu… - Kidney and Blood …, 2023 - karger.com
Introduction: Numerous research works have shown that serum Gal-deficient (Gd) IgA1
levels are increased in IgA nephropathy (IgAN) patients and these levels are a dangerous …

IgA nephropathy: an update

BA Julian, J Novak - Current opinion in nephrology and …, 2004 - journals.lww.com
A better understanding of the mechanisms underlying the synthesis of galactose-deficient
IgA1, the formation of circulating immune complexes, and interactions with mesangial cells …

Biomarkers and targeted new therapies for IgA nephropathy

R Coppo - Pediatric Nephrology, 2017 - Springer
IgA nephropathy (IgAN) has variable clinical presentation and outcome. There is a need to
identify children who have the potential to progress to end stage renal disease (ESRD) …

The mucosal immune system and IgA nephropathy

L Gesualdo, V Di Leo, R Coppo - Seminars in immunopathology, 2021 - Springer
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

Cellular signaling and production of galactose‐deficient IgA1 in IgA nephropathy, an autoimmune disease

C Reily, H Ueda, ZQ Huang, J Mestecky… - Journal of …, 2014 - Wiley Online Library
Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary
glomerulonephritis, is characterized by IgA1‐containing immunodeposits in the glomeruli …