[HTML][HTML] Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

T Kim, D Yi, MS Byun, H Ahn, JH Jung, N Kong… - Alzheimer's research & …, 2022 - Springer
Background Hypertension has been associated with Alzheimer's disease (AD) dementia as
well as vascular dementia. However, the underlying neuropathological changes that link …

Tau pathologies mediate the association of blood pressure with cognitive impairment in adults without dementia: the CABLE study

H Hu, L Meng, YL Bi, W Zhang, W Xu… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction This study delineated the interrelationships among blood pressure (BP),
cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition …

Role of Hypertension in Aggravating Aβ Neuropathology of AD Type and Tau‐MediatedMotor Impairment

C Diaz-Ruiz, J Wang, H Ksiezak-Reding… - Cardiovascular …, 2009 - Wiley Online Library
Epidemiological evidence suggests that hypertension may accelerate the onset and
progression of Alzheimer′ s disease (AD). In this study, we explored the role of …

Visit-to-visit blood pressure variability and longitudinal tau accumulation in older adults

IJ Sible, DA Nation - Hypertension, 2022 - Am Heart Assoc
Background: Elevated blood pressure variability (BPV) is predictive of dementia,
independent of average blood pressure levels, but neuropathological mechanisms remain …

Walking the cognitive “minefield” between high and low blood pressure

S Kennelly, O Collins - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Vascular risk factors are implicated in the pathogenesis of Alzheimer's disease (AD). There
is an age-dependent relationship between blood pressure and the risk of AD. Given the …

Blood Pressure Variability and Plasma Alzheimer's Disease Biomarkers in the SPRINT Trial

IJ Sible, DA Nation - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Background: Recent observational studies suggest higher blood pressure (BP) variability
(BPV) is associated with Alzheimer's disease (AD) biomarkers amyloid-beta (Aβ) and tau …

Anti-Hypertensive Drugs Moderate the Relationship of Blood Pressure with Alzheimer's Pathologies and Neurodegenerative Markers in Non-Demented Hypertensive …

Y Guo, CC Tan, MS Tan, L Tan, W Xu - The Journal of Prevention of …, 2024 - Springer
Background We aimed to explore whether the relationships of blood pressures (BPs) with
Alzheimer's disease (AD) endophenotypes varied by usage of antihypertensive drugs …

Midlife blood pressure, plasma β-amyloid, and the risk for Alzheimer disease: the Honolulu Asia Aging Study

NS Shah, JS Vidal, K Masaki, H Petrovitch… - …, 2012 - Am Heart Assoc
β-Amyloid (Aβ), a vasoactive protein, and elevated blood pressure (BP) levels are
associated with Alzheimer disease (AD) and possibly vascular dementia. We investigated …

Influence of hypertension on brain amyloid deposition and Alzheimer's disease signature neurodegeneration

SY Jeon, MS Byun, D Yi, JH Lee, YM Choe, K Ko… - Neurobiology of …, 2019 - Elsevier
This study aimed to investigate the relationship of hypertension with beta-amyloid (Aβ) and
neurodegeneration biomarkers of Alzheimer's disease (AD) and the modulating effect of …

Pathophysiological association of alzheimer's disease and hypertension: A clinical concern for elderly population

Q Yao, K Jiang, F Lin, T Zhu, NH Khan… - Clinical Interventions in …, 2023 - Taylor & Francis
Abstract Alzheimer's disease (AD), the most common cause of dementia and the fifth leading
cause of death in the adult population has a complex pathophysiological link with …