Vascular risk and β‐amyloid are synergistically associated with cortical tau

JS Rabin, HS Yang, AP Schultz… - Annals of …, 2019 - Wiley Online Library
Objective Neuropathological studies have demonstrated that cerebrovascular disease and
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …

Effects of hypertension and anti-hypertensive treatment on amyloid-β (Aβ) plaque load and Aβ-synthesizing and Aβ-degrading enzymes in frontal cortex

EL Ashby, JS Miners, PG Kehoe… - Journal of Alzheimer's …, 2016 - content.iospress.com
Epidemiological data associate hypertension with a predisposition to Alzheimer's disease
(AD), and a number of postmortem and in vivo studies also demonstrate that hypertension …

Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease

A Csiszar, Z Tucsek, P Toth… - American Journal …, 2013 - journals.physiology.org
Strong epidemiological and experimental evidence indicate that hypertension in the elderly
predisposes to the development of Alzheimer's disease (AD), but the underlying …

Blood pressure and the risk of Alzheimer's disease: is there a link?

M Yuan, S Chen, X Li, L Xu - American Journal of …, 2016 - journals.sagepub.com
Alzheimer disease is one of the most common neurodegenerative disorder, and the
incidence is increasing. Many epidemiologic studies have considered the association …

Blood pressure variability predicts cognitive decline in Alzheimer's disease patients

S Lattanzi, S Luzzi, L Provinciali, M Silvestrini - Neurobiology of aging, 2014 - Elsevier
The aim of our study was to evaluate whether blood pressure variability influences the rate
of cognitive decline in Alzheimer's disease (AD). Two hundred and forty AD patients were …

Hypertension and Alzheimer Disease: Another Brick in the Wall of Awareness

E Thorin - Hypertension, 2015 - Am Heart Assoc
soluble Aβ42. It is not unusual to observe such endothelial overcompensation in response to
metabolic stress induced by transient brain ischemia, for example, but these adaptive …

[HTML][HTML] Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities

WJ Cha, D Yi, H Ahn, MS Byun, YY Chang… - Alzheimer's Research & …, 2024 - Springer
Background Growing evidence suggests that not only cerebrovascular disease but also
Alzheimer's disease (AD) pathological process itself cause cerebral white matter …

Blood pressure is associated with higher brain amyloid burden and lower glucose metabolism in healthy late middle-age persons

JBS Langbaum, K Chen, LJ Launer, AS Fleisher… - Neurobiology of …, 2012 - Elsevier
Epidemiological studies suggest that elevated blood pressure (BP) in midlife is associated
with increased risk of Alzheimer's disease (AD) in late life. In this preliminary study, we …

High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders

CM Fiford, JM Nicholas, GJ Biessels… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Understanding relationships among blood pressure (BP), cognition, and brain
volume could inform Alzheimer's disease (AD) management. Methods We investigated …

Blood pressure, white matter lesions and medial temporal lobe atrophy: closing the gap between vascular pathology and Alzheimer's disease?

ESC Korf, P Scheltens, F Barkhof… - Dementia and geriatric …, 2005 - karger.com
Background: Vascular factors are recognized as important risk factors for Alzheimer's
disease, although it is unknown whether these factors directly lead to the typical …