Human pluripotent stem cells (hPSC) have the potential to produce any tissue type in the
body and thus represent a source of cells for regenerative medicine. Here we have shown …

Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Background The production of human platelets from embryonic stem cells in a defined
culture system is a prerequisite for the generation of platelets for therapeutic use. As an …

Human pluripotent stem cells [PSCs; including human embryonic stem cells (ESCs) and
induced pluripotent stem cells (iPSCs)] can infinitely proliferate in vitro and are easily …

Human embryonic stem cells (hESCs) represent a potential source of blood cells for
transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis …

Platelet deficiency, known as thrombocytopenia, can cause haemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells …

Since becoming standard clinical practice, platelet transfusions have depended on donors.
Because of changing population demographics, however, many nations anticipate chronic …

Ex vivo production of human platelets has been pursued as an alternative measure to
resolve limitations in the supply and safety of current platelet transfusion products. To this …

Platelets (PLTs) are small anucleate blood cells that release from polyploidy
megakaryocytes (MKs). PLT transfusion is standard therapy to prevent hemorrhage. PLT …